A RARE TUMOR – ADRENAL ANGIOSARCOMA
Keywords:adrenal angiosarcoma, suprarenal, adrenalectomy, vasoformative tumor
Background. Primary adrenal angiosarcoma is an exceptionally rare tumor with an incidence of <1% of soft tissue sarcomas. Less than 50 cases being described in literature; most of them were nonfunctional presenting with symptoms of abdominal lump, weight loss, fatigue or weakness. The treatment remains multi-modal with involvement of surgeon as well as medical oncologist.
Objective. The aim of this case report is to describe an entity which is rare in terms of incidence. It was functional as well as metastatic and managed with multimodality therapy.
Methods. The case is a 47-year-old man diagnosed with metastatic adrenal angiosarcoma. The patient was managed with chemotherapy followed by surgery.
Results. The final histopathological examination of the specimen and immunohistochemistry revealed angiosarcoma. At present the patient is under follow-up.
Conclusion. Even though surgery forms the main stay of management, the role of multi-modality therapy forms the cornerstone for adrenal angiosarcomas.
Weiss SW, Goldblum JR, Folpe AL. Enzinger and Weiss’s Soft Tissue Tumors. Elsevier Health Sciences; 2007. 4348 p.
Li XM, Yang H, Reng J, Zhou P, Cheng ZZ, Li Z, et al. A case report of primary adrenal angiosarcoma as depicted on magnetic resonance imaging. Medicine (Baltimore). 2017 Nov 10;96(45):e8551.
Grajales-Cruz A, Baco-Viera F, Rivé-Mora E, Ramírez-Tanchez C, Tasso D, Arroyo-Portela N, et al. Primary Adrenal Angiosarcoma: A Rare and Potentially Misdiagnosed Tumor. Cancer Control. 2017 Apr;24(2):198-201.
Stavridis S, Mickovski A, Filipovski V, Sasho B, Sasho D, Ljupcho L. Epithelioid Angiosarcoma of the Adrenal Gland. Report of a Case and Review of the Literature. Maced J Med Sci. 2010 Dec 15;3.
Antao N, Ogawa M, Ahmed Z, Piao J, Poddar N. Adrenal Angiosarcoma: A Diagnostic Dilemma. Cureus. 11(8):e5370.
Kareti LR, Katlein S, Siew S, Blauvelt A. Angiosarcoma of the adrenal gland. Arch Pathol Lab Med. 1988 Nov;112(11):1163-5.
Fuletra JG, Ristau BT, Milestone B, Cooper HS, Browne A, Movva S, et al. Angiosarcoma of the Adrenal Gland Treated Using a Multimodal Approach. Urol Case Rep. 2016 Dec 1;10:38-41.
Livaditou A, Alexiou G, Floros D, Filippidis T, Dosios T, Bays D. Epithelioid Angiosarcoma of the Adrenal Gland Associated with Chronic Arsenical Intoxication? Pathol - Res Pract. 1991 Mar 1;187(2): 284-9.
Kumar A, Popli V, roy N, Jafri H, Ponnam A. Giant adrenal endothelial Cyst: A case report. Med Sci Int Med J. 2022 Aug 21;11.
Sung JY, Ahn S, Kim SJ, Park YS, Choi YL. Angiosarcoma arising within a long-standing cystic lesion of the adrenal gland: a case report. J Clin Oncol Off J Am Soc Clin Oncol. 2013 Mar 20;31(9):e132-6.
Rodriguez-Pinilla SM, Benito-Berlinches AB, Ballestin C, et al. Angiosarcoma of adrenal gland: report of a case and review of the literature. Rev Esp Patol. 2002;35(2):227-32.
Criscuolo M, Valerio J, Gianicolo ME, et al. A vinyl chloride-exposed worker with an adrenal gland angiosarcoma: a case report. Ind Health. 2014; 52(1):66-70.
Hendry S, Forrest C. Epithelioid angiosarcoma arising in an adrenal cortical adenoma: a case report and review of the literature. Int J Surg Pathol. 2014;22(8):744-8.
National Institutes of Health. NIH state-of-the-science statement on management of the clinically inapparent adrenal mass (“incidentaloma”) NIH Consens State Sci Statements. 2002;19(2):1-25.
How to Cite
Copyright (c) 2023 International Journal of Medicine and Medical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who sent their manuscript to International Journal of Medicine and Medical Research agree to the following terms:
1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License CC-BY-NC that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
2. Authors able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).