ELAEOCARPUS SERRATUS L. EXHIBITS POTENTIAL ANALGESIC AND ANTIDIARRHEAL ACTIVITIES IN MICE MODEL

Authors

DOI:

https://doi.org/10.11603/ijmmr.2413-6077.2020.2.11388

Keywords:

Elaeocarpus serratus, analgesic activity, antidiarrheal activity, hypoglycemic activity

Abstract

Background. Elaeocarpus serratus L. (Family: Elaeocarpaceae) is a tropical fruit tree, traditionally used in the treatments of poisoning, diarrhea, arthritis, and other diseases.

Objectives. The current study was performed to conduct the analgesic, antidiarrheal, and hypoglycemic activity of E. serratus in mice model using methanolic bark crude extract.

Methods. To assess the peripheral and central analgesic activity, the acetic acid-induced writhing and tail immersion methods were respectively used. The castor-oil mediated antidiarrheal method was used to assess the antidiarrheal activity whereas, the tail tipping technique was conducted to determine the hypoglycemic activity of the plant extract.

Results. In the peripheral analgesic assay, the methanolic bark crude extract of E. serratus significantly inhibits the number of writing 69.77% (200 mg/kg) and 73.26% (400 mg/kg) respectively (p<0.05) which was strongly comparable with standard NSAID drug diclofenac sodium 75.58% (p<0.05). Similarly, it shown a significant tail flicking response for 30 minutes, 60 minutes and 90 minutes of central analgesic activity assay. In antidiarrheal activity assay, the E. serratus substantially reduced the number of diarrheal feces 64.26% (200 mg/kg, p<0.05) and 78.57% (400 mg/kg, p<0.05) which was also comparable with the positive control loperamide. The hypoglycemic activity of E. serratus extract was not convincing.

Conclusions. Our investigation demonstrated the significant analgesic and antidiarrheal activities of methanolic bark extract of E. serratus (200 and 400 mg/kg) in mice model.

Author Biographies

A. A. H. Pinkey, DEPARTMENT OF PHARMACY, STATE UNIVERSITY OF BANGLADESH, DHAKA, BANGLADESH

graduate student, State University of Bangladesh, Dhaka, Bangladesh

Z. I. Khan, DEPARTMENT OF HEALTH TECHNOLOGY AND INFORMATICS, THE HONG KONG POLYTECHNIC UNIVERSITY, HONG KONG, CHINA

full-time PhD student, The Hong Kong Polytechnic University, Hong Kong, China

M. A. Taher, DEPARTMENT OF PHARMACY, STATE UNIVERSITY OF BANGLADESH, DHAKA, BANGLADESH

lecturer and Student Counselor, State University of Bangladesh, Dhaka, Bangladesh

M. A. Soma, DEPARTMENT OF PHARMACY, STATE UNIVERSITY OF BANGLADESH, DHAKA, BANGLADESH

lecturer and Student Counselor, State University of Bangladesh, Dhaka, Bangladesh

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Published

2021-05-18

How to Cite

Pinkey, A. A. H., Khan, Z. I., Taher, M. A., & Soma, M. A. (2021). ELAEOCARPUS SERRATUS L. EXHIBITS POTENTIAL ANALGESIC AND ANTIDIARRHEAL ACTIVITIES IN MICE MODEL. International Journal of Medicine and Medical Research, 6(2), 44–51. https://doi.org/10.11603/ijmmr.2413-6077.2020.2.11388