NONSPECIFIC DYSPLASIA OF THE CONNECTIVE TISSUE – A FACTOR OF VENOUS THROMBOEMBOLIC COMPLICATIONS IN ENDOPROSTHETICS OF HIP JOINTS

Authors

DOI:

https://doi.org/10.11603/ijmmr.2413-6077.2020.1.11047

Keywords:

endoprosthetics, thromboembolism, endothelial dysfunction, dysplasia

Abstract

Background. Important part of orthopedic surgery is endoprosthetics of hip joints, which eliminates pain syndrome, restores the amplitude of movement and the support ability of lower limbs. But some complications usually take place; venous thromboembolism is leading among them.

Objective. The aim of the study was to investigate endothelial dysfunction and activity of the hemocoagulation system at different levels of VTEC risks and thus to work out the strategy of thromboprophylaxis in patients with osteoarthrosis of the hip joint and femoral neck fracture combined with non-specific dysplasia of the connective tissue.

Methods. 219 patients of a mean age of 64.7±3.8 years old underwent surgery. In 137 (62.1%) cases, a total cement hip replacement was performed for osteoarthritis. 82 (37.4%) patients underwent total and unipolar cement hip replacement for cervical femoral neck fractures.

Results. Clinical manifestations of non-specific connective tissue dysplasia were detected in 83 (37.9%) patients that was confirmed by the laboratory determination of the level of general, bound and free oxyproline. In the postoperative period, the thrombotic process in the venous system of the inferior vena cava was diagnosed in 23 (10.5%) cases. The level of indicators of endothelium status dysfunction was much more significant in the patients in cases of nonspecific dysplasia of connective tissue. Operative intervention on the hip joint in the patients with nonspecific dysplasia of connective tissue in 11 (13.3%) cases was complicated by development of venous thrombosis. In the patients without non-specific connective tissue dysplasia, postoperative thrombosis in the system of the inferior vena cava was diagnosed in 12 (8.8%) cases.

Conclusions. Patients with osteoarthrosis of the hip joint and the femoral neck fracture accompanied by the non-specific dysplasia of the connective tissue are characterized by high levels of endothelial dysfunction and increased activity of the blood-coagulation system.

Author Biographies

I. K. Venher, I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

доктор медичних наук, професор, завідувач кафедри хірургії № 2, Тернопільський національний медичний університет імені І.Я. Горбачевського, Тернопіль, Україна

N. I. Herasymiuk, I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

MD, Ph.D., Professor, Department of Surgery No. 2, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

S. Ya. Kostiv, I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

MD, Ph.D., Professor, Department of Surgery No. 2, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

I. I. Loyko, I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

MD, Ph.D., Professor, Department of Surgery No. 2, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

D. V. Khvalyboha, I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

MD, postgraduate student, Department of Surgery No. 2, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

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Published

2020-11-10

How to Cite

Venher, I. K., Herasymiuk, N. I., Kostiv, S. Y., Loyko, I. I., & Khvalyboha, D. V. (2020). NONSPECIFIC DYSPLASIA OF THE CONNECTIVE TISSUE – A FACTOR OF VENOUS THROMBOEMBOLIC COMPLICATIONS IN ENDOPROSTHETICS OF HIP JOINTS. International Journal of Medicine and Medical Research, 6(1), 35–42. https://doi.org/10.11603/ijmmr.2413-6077.2020.1.11047