GENDER-SPECIFIC DIFFERENCES OF CARDIAC VEGETATIVE CONTROL IN ADRENALINE-INDUCED NECROSIS AND LIGHT DEPRIVATION

Keywords: myocardial necrosis, heart rhythm variability, light deprivation, gender

Abstract

Background. Cardiovascular disease is the main cause of morbidity predominantly in males. Stress is one of the crucial factors, especially with light desynchronosis.

Objective of the study was to assess gender-specific characteristics of cardiac vegetative control in myocardial necrosis in cases of light deprivation.

Methods. Cardiac vegetative control in adrenaline-induced myocardial necrosis (AIMN) in a setting of light deprivation (LD) was assessed in 72 mature white rats of both sexes. The animals were divided into 2 groups: G1 – the animals kept under day/night cyclic balance (12 hours/12 hours); G2 – the animals kept at LD (illumination 0.5-1 LX) for 10 days. On Day 11, AIMN caused by adrenaline (0.5 mg/kg) and heart rate variability (HRV) was assessed in 1 hour and 24 hours.

Results. The development of AIMN at LD in the ♂G2 led to HRV increase that was caused by augmentation of parasympathetic and reduction of sympathetic cardiac effects. In cases of AIMN, changes of CVC in the ♀G2 were similar to the ♀G1. However, in 1 hour of AIMN, parasympathetic cardiac effects were more significant than in the ♀G1. While the ♀G2 AIMN animals experienced balanced sympathetic and parasympathetic actions, the predominance of the sympathetic component was evidenced in the ♀G1 AIMN animals.

Conclusions. Light deprivation has different effects on baseline sympathetic/parasympathetic balance in males and females, i.e. increased parasympathetic control of heart rhythm in males and maintenance of sympathetic/ parasympathetic balance in females.

Author Biographies

H. O. Bezkorovaina, I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

MD, Ph.D. Student, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

I. M. Klishch, I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

MD, Ph.D., DSc, Professor, Functional and Clinical diagnostics Department, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

M. R. Khara, I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

MD, Ph.D., DSc, Professor, Pathophysiology Department, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

V. Ye. Pelykh, I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

MD, PhD, Associate Professor of Pathophysiology Department, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

References

Townsend N, Wilson L, Bhatnagar P, Wickra­masinghe K, Rayner M, Nichols M. Cardiovascular disease in Europe: epidemiological update 2016. European Heart Journal. 2016 Aug 14;37(42):3232-45.

Roth GA, Forouzanfar MH, Moran AE, Barber R, Nguyen G, Feigin VL, Naghavi M, Mensah GA, Murray CJ. Demographic and epidemiologic drivers of global cardiovascular mortality. New England Journal of Medicine. 2015 Apr 2;372(14):1333-41.

doi: 10.1056/NEJMoa1406656

EUGenMed, Cardiovascular Clinical Study Group, Regitz-Zagrosek V, Oertelt-Prigione S, Prescott E, Franconi F, Gerdts E, Foryst-Ludwig A, Maas AH, Kautzky-Willer A, Knappe-Wegner D. Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes. Euro­pean Heart Journal. 2015 Nov 3;37(1):24-34.

doi: 10.1093/eurheartj/ehv598

Pyle WG, Martino TA. Circadian rhythms influence cardiovascular disease differently in males and females: role of sex and gender. Current Opinion in Physiology. 2018 Oct 1;5:30-7.

doi:10.1016/j.cophys.2018.05.003

Reitz CJ, Martino TA. Disruption of circadian rhythms and sleep on critical illness and the impact on cardiovascular events. Current pharmaceutical design. 2015 Jul 1;21(24):3505-11.

Ariznavarreta C, Cardinali DP, Villanúa MA, Granados B, Martín M, Chiesa JJ, Golombek DA, and Tresguerres JA. Circadian rhythms in airline pilots submitted to long-haul transmeridian flights. Avia­tion, Space, and Environmental Medicine. 2002;73(5): 445-455. PMID: 12014603

Wulff K, Dijk DJ, Middleton B, Foster RG. Sleep and circadian rhythm disruption in schizophrenia. British Journal of Psychiatry.2012;200(4):308-16.

doi: 10.1192/bjp.bp.111.096321

Molcan L, Sutovska H, Okuliarova M, Senko T, Krskova L, Zeman M. Dim light at night attenuates circadian rhythms in the cardiovascular system and suppresses melatonin in rats. Life Sci. 2019;231:116568.

doi: 10.1016/j.lfs.2019.116568

Pandi-Perumal SR, Srinivasan V, Maestroni GJM, Cardinali DP, Poeggeler B, Hardeland R. Melatonin. Nature’s most versatile biological signal? FEBS Journal. 2006;273(13):2813-38.

Gunn PJ, Middleton B, DaviesSK, Revell VL, Skene DJ. Sex differences in the circadian profiles of melatonin and cortisol in plasma and urine matrices under constant routine conditions. Chronobiol. Int. 2016;33(1):39–50.

doi: 10.3109/07420528.2015.1112396

Khara MR, Shkumbatiuk OV. Sex aspects of melatonin involvement in the regulation of heart rhythm in adrenaline damage. Clinical and Experi­mental Pathology. 2013; 46(4):126-129. [in Ukrainian]

Lin WL, Chen HR, Lo LW, Lai CT, Yamada S, Liu SH, Chou YH, Chen SA, Fu YC, Kuo TB. Sleep-related changes in cardiovascular autonomic regulation in left coronary artery ligation rats: Neural mechanism facilitating arrhythmia after myocardial infarction. International Journal of Cardiology. 2016 Dec 15;225:65-72.

doi: 10.1016/j.ijcard.2016.09.121

Khara MR, Shkumbatiuk OV. Sex differences in metabolic changes in the myocardium in the development of a necrotic process against melatonin. Actual problems of transport medicine. 2014;36(2, p-II):47-52. [in Ukrainian]

Kolettis TM, Kontonika M, Lekkas P, Vlahos AP, Baltogiannis GG, Gatzoulis KA, Chrousos GP. Auto­nomic responses during acute myocardial infarction in the rat model: implications for arrhythmogenesis. J Basic Clin Physiol Pharmacol. 2018;29(4):339-45.

doi: 10.1515/jbcpp-2017-0202

Baevsky RM., Ivanov GG., Chireikin LV. Ana­lysis of heart rhythm variability when using various electrocardiographic systems (guidelines) // Bulletin of Arrhythmology. 2001;24:65–87. [in Russian].

Buoy MZ, Taratukhin EO. Possibilities of the method of heart rhythm variability. Russian Journal of Cardiology. 2011;6(92):69-75. [in Russian]

Thandroyen FT, Opie LH. Catecholamine-induced myocardial cell damage: Catecholamines or adrenochrome. J Mol Cell Cardiol. 1985;17(4):349-359.

Ahmed SS, Strobel HW, Napoli KL, Grevel J. Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes. J Pharmacol Experim Therap. 1993;265(3):1047-54.

Khara MR, Bodnar YaYa, Fayfura VV. Features of structural changes in the heart of animals of dif­ferent sex in the modelling of adrenaline myocardio­dystrophy // Rus Morphol Statements. 2000;1(2):289-290. [in Ukrainian]

Khara MR. Influence of trasicor on cholinergic reactions of heart of animals of different sex with adrenaline myocardiodystrophy. Galician Medical Bulletin. 2004;11(1):110-2. [in Ukrainian]

Khara MR. The modulating effect of carba­cholin and castration on the cholinergic regulation of cardiac rhythm different sex rats in conditions of adrenaline myocardial damage. Bull Ukrain Dent Acad. 2003;3(2):13-5. [in Ukrainian]

Anishchenko TG, Igosheva IB. Sex differences of stress reactivity in awake and anesthetized rats under surgical stress. Bull Experim Biol Med. 1992; 113(1):26-8. [in Russian]

Talaei SA, Sheibani V, Salami M. Light depri­vation improves melatonin related suppression of hippocampal plasticity. Hippocampus. 2010;20(3): 447-55.

doi: 10.1002/hipo.20650

Cain SW, Dennison CF, Zeitzer JM, Guzik AM, Khalsa SB, Santhi N, Schoen MW, Czeisler CA, Duffy JF. Sex differences in phase angle of entrainment and melatonin amplitude in humans. J Biol Rhythms. 2010;25(4):288-96.

doi: 10.1177/0748730410374943

Published
2020-02-27
How to Cite
Bezkorovaina, H. O., Klishch, I. M., Khara, M. R., & Pelykh, V. Y. (2020). GENDER-SPECIFIC DIFFERENCES OF CARDIAC VEGETATIVE CONTROL IN ADRENALINE-INDUCED NECROSIS AND LIGHT DEPRIVATION . International Journal of Medicine and Medical Research, 5(2), 137-144. https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10902