METHODS OF METOPROLOL ANALYSIS IN DRUGS AND BIOLOGICAL FLUIDS: REVIEW AND SUGGESTIONS
Background. Analytical method is increasingly implemented into fundamental pharmaceutical chemistry and analysis, considering their high sensitivity, accuracy, specificity and expressiveness.
Objective. Metoprolol’s analytical method development was the research goal.
Methods. The sources were world recognized journals (1990-2019) and key words used as filter were “metoprolol”, “spectrophotometry” “high-performance liquid chromatography, HPLC”, “quantitative analysis”, “validation”.
Results. Chromatographic methods of analysis have the highest specificity and objectivity and allow qualitative and quantitative determination of Active Pharmaceutic Ingredient (API) in combined dosage forms and biological fluids without prior components separation. The main disadvantage of the described API analysis methods is long terms from the beginning of chromatography to API release and specific solvents used as the mobile phase in HPLC. New methods development and selection such chromatographic conditions that provide high speed and high efficiency at lower pressure of the system are essential. Also, the reduction of analysis time is achieved by simplifying the conditions for sample preparation.
Conclusions. Analysts are constantly working on developing new analysis methods and their optimization in order to save time and consumables, which also ensures the efficiency of the developed method. There is no monograph on the substance or dosage forms of metoprolol in SPhU. Therefore, some of the developed methods should be suggested for the SPhU monograph, which is important for ensuring pharmacopoeial quality control of medicines in Ukraine.
Metoprolol Succinate Extended-Release Tablets. Tablets: 25 Mg, 50 Mg, 100 Mg, and 200 Mg. NDA 19-962/S-032:3. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/ 019962s032lbl.pdf. Accessed 13 Jan 2019.
Neagoe AM, Rexhaj E, Grossman E, Messerli FH. Beta Blockers and Calcium Channel Blockers. InCardiovascular Hemodynamics 2019 (pp. 73-88). Humana, Cham.
U.S. National Library of Medicine. National Center for Biotechnology Information. Available from: https://pubchem.ncbi.nlm.nih.gov. Accessed 19 Jan 2019.
Metoprolol Succinate Extended-Release Tablets. Revision Bulletin. Expert Committee Chemical Medicines Monographs 2. Available from: https://www.uspnf.com/sites/default/files/usp_pdf/EN/USPNF/revisions/metoprolol-succinate-ert-rb-notice.pdf. Accessed 19 Jan 2019.
U.S. Pharmacopeia. Search USP29. Metoprolol Tartrate Tablets. Available from: http://www.pharmacopeia.cn/v29240/usp29nf24s0_m53550.html. Accessed 20 Jan 2019.
Cesme M, Tarinc D, Golcu A. Spectrophotometric Determination of metoprolol tartrate in pharmaceutical dosage forms on complex formation with Cu(II). Pharmaceuticals (Basel). 2011;4(7):964-75.
Nabil AF, Eman MS. Spectrophotometric determination of metoprolol in pharmaceutical formulation by charge transfer complexation. International Journal of Chemical Studies. 2015;3(2):24-9.
Donchenko A, Vasyuk S. Spectrophotometric determination of metoprolol tartrate in pure and dosage forms. J. Fac. Pharm. Ankara. 2018;42(1):33-42.
Yilmaz B. Determination of metoprolol in pharmaceutical preparations by zero-, first-, second- and third- order derivative spectrophotometric method. Int J of Pharma and Bio Sci. 2010;12(1):1-15.
Jadhav AS, Tarkase KN, Deshpande AP. Quantitative determination of metoprolol succinate in bulk and tablet Dosage form through comparative study of UV and derivative Spectroscopy. Der Pharmacia Lettre. 2012;4(3):763-7.
Rahman N, Rahman H, Aami SN. Validated Kinetic Spectrophotometric Method for the Determination of Metoprolol Tartarate in Pharmaceutical Formulations. Chem. Pharm. Bull. 2005;53(8):942-8.
Hussain S, Munjewar RR, Farooqui M. Development and validation of a simultaneous HPLC method for quantification of amlodipine besylate and metoprolol tartrate in tablets. Journal of Pharmascitech. 2012;1(2):1-5.
Singh BK, Patel DK, Ghosh SK. Development of Reverse-Phase HPLC method for simultaneous analysis of metoprolol succinate and hydrochlorothiazide in a tablet formulation. Tropical Journal of Pharmaceutical Research. 2009;8(6):539-43.
Prasad PH, Patel PM, Vijaysree D, Reddy YS, Ranjith Kumar B. Simultaneous estimation of metoprolol tartrate and chlorthalidone by using RP-HPLC and method development as per ICH guidelines. Der Pharma Chemica. 2013;5(5):139-43.
Mahaparale SP, Gonjari ID, Jayaveera KN. Stability indicating HPLC method for simultaneous estimation of metoprolol succinate and termisartan. Journal of Liquid Chromatography & Related Technologies. 2013;36:2601-11.
Braza AJ, Modamio P, Lastra CF, Marino EL. Development, validation and analytical error function of two chromatographic methods with fluorometric detection for the determination of bisoprolol and metoprolol in human plasma. Biomed Chromatogr. 2002;16:517-22.
Chiu FCK, Damani LA, Li RC, Tomlinson B. Efficient high-performance liquid chromatographic assay for the simultaneous determination of metoprolol and two main metabolites in human urine by solid-phase extraction and fluorescence detection. J Chromatogr B. 1997;696:69-74.
Johnson RD, Lewis RJ. Quantitation of atenolol, metoprolol, and propranolol in postmortem human fluid and tissue specimens via LC/APCI-MS. Forensic Sci Int. 2006;156:106-17.
Jensen BP, Sharp CF, Gardiner SJ, Begg EJ. Development and validation of a stereoselective liquid chromatography tandem mass spectrometry assay for quantification of S and R-metoprolol in human plasma. J Chromatogr B. 2008;865:48-54.
Gowda KV, Mandal U, Selvan PS, Solomon WDS, Ghosh A, Sarkar AK, et al. Liquid chromatography tandem mass spectrometry method for simultaneous determination of metoprolol tartrate and ramipril in human plasma. J Chromatogr B. 2007;858:13-21.
Albers S, Elshoff JP, Volker C, Richter A, Laer S. HPLC quantification of metoprolol with solid-phase extraction for the drug monitoring of pediatric patients. Biomed Chromatogr. 2005;19:202-7.
Angier MK, Lewis RJ, Chaturvedi AK, Canfield DV. Gas chromatographic-mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol. J Anal Toxicol. 2005;29:517-21.
Logoyda L. Analysis of approaches to the development and validation of the methods of analysis of some active pharmaceutical ingredients from the group of calcium channel blockers in drugs and biological liquids. International Journal of Applied Pharmaceutics. 2019;11(3):26-34.
Logoyda L. Analysis of approaches to the development and validation of the methods of analysis of some active pharmaceutical ingredients from the group of angiotensin converting enzyme inhibitors in drugs and biological liquids. International Journal of Applied Pharmaceutics. 2019;11(4):1-7.
Copyright (c) 2020 International Journal of Medicine and Medical Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who sent their manuscript to International Journal of Medicine and Medical Research agree to the following terms:
1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License CC-BY-NC that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
2. Authors able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).