PRIMARY EPISODE OF BIPOLAR AFFECTIVE DISORDER

Keywords: bipolar affective disorder, individual-psychological features, depressive, manic and mixed variants

Abstract

Background. Bipolar affective disorder (BAD) is a topical issue of contemporary psychiatry. The features of the primary episode (PE) of the disease are extremely important for prognosis, treatment and rehabilitation measures of BAD. Individual psychological features of the patients with PE of BAD are still unexplored that complicates development of new methods of prediction, treatment and prevention of BAD.

Objective. The aim of the study was to investigate individual psychological features of the patients with a primary episode of bipolar affective disorder, taking into account the gender factor and clinical variant of the BAD debut.

Methods. 153 patients (65 men and 88 women) with a primary episode of bipolar affective disorder were examined. The patients were divided into three groups according to the clinical variant of the course of PE of BAD: depressive variant, manic variant and mixed variant. The examination was carried out using the Standardized multifactor method of personality research (SMMPR). Statistical processing of the data was performed using the non-parametric Mann-Whitney test.

Results. The most significant differences in the quantitative indicators of SMMPR were found when comparing depressive and manic, as well as depressive and mixed variants of PE of BAD, and lesser – when comparing manic and mixed variants. Most of all, these differences were expressed in terms of pessimism, impulsiveness, individualism and optimism. 

Conclusions. Some peculiar features of male and female patients with depressive, manic and mixed variants of PE of BAD promoting to search for new methods of prediction, treatment and prevention of BAD have been defined.

Author Biography

Yu. I. Mysula, I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

MD, PhD, Associate Professor of the Department of Psychiatry, Necrology and Medical Psychology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

References

Mental health: strengthening our response (2018). Information Bulletin of World Health Orga­nisation. Geneva, WHO. 1-28.

Patel R, Shetty H, Jackson R, Broadbent M, Stewart R, Boydell J, et al. Delays before diagnosis and initiation of treatment in patients presenting to mental health services with bipolar disorder. PLoS One. 2015;10:126-9.

doi: 10.1371/journal.pone.0126530

Chakrabarty T, Alamian G, Kozicky JM, Ivan JT, Lakshmi NY. Cognitive functioning in first episode bipolar I disorder patients with and without history of psychosis. Journal of Affective Disorders. 2018;227:109-16.

doi: 10.1016/j.jad.2017.10.003

Sam SP, Nisha A, Varghese PJ. Stressful Life Events and Relapse in Bipolar Affective Disorder: A Cross-Sectional Study from a Tertiary Care Center of Southern India. Indian Journal of Psychological Medicine. 2019; 41(1):61-7.

Tondo L, Vázquez GH, Baldessarini RJ. De­pression and Mania in Bipolar Disorder. Current Neuropharmacology. 2017;15(3):353-8.

doi: 10.2174/1570159X14666160606210811

Kessing LV, Miskowiak K. Does Cognitive Dysfunction in Bipolar Disorder Qualify as a Diagnostic Intermediate Phenotype? Frontiers in Psychiatry. 2018;9:490.

doi: 10.3389/fpsyt.2018.00490

Hayes JF, Miles J, Walters K, et al. A systematic review and meta-analysis of premature mortality in bipolar affective disorder. Acta Psychiatrica Scan­dinavica. 2015;131:417-25.

doi: 10.1111/acps.12408

Rowland TA, Marwaha S. Epidemiology and risk factors for bipolar disorder. Therapeutic Advan­ces in Psychopharmacology. 2018;8(9):251-69.

doi: 10.1177/2045125318769235

Baldessarini RJ, Tondo L, Visioli C. First-episode types in bipolar disorder: predictive associations with later illness. Acta Psychiatrica Scandinavica. 2014; 129:383-92.

doi: 10.1111/acps.12204

Venger OP, Mysula YI, Shkrobot LV. Improvement of the approaches to the treatment of emigrants and the re-emigrants with depressive disorders. International Journal of Medicine and Medical Research. 2017;3(1):5-10.

doi: 10.11603/ijmmr.2413-6077.2017.1.7039

Latalova K, Prasko J, Kamaradova D, Sed­lackova Z, Ociskova M. Comorbidity bipolar disorder and personality disorders. Neuroendocrinology letters. 2013;34 (4):2-8.

Sobchik LN. Standardized multivariate personality research method. Sanct-Peterburg: Rech, 2003. 218 p. (In Russian).

Gudmundsson E. The bipolar II disorder personality traits, a true syndrome? J Affect Disord. 2015;178:107-11.

doi: 10.1016/j.jad.2015.02.030

Bortolato B, Kohler CA, Evangelou E, et al. Systematic assessment of environmental risk factors for bipolar disorder: an umbrella review of systematic reviews and meta-analyses. Bipolar Disord. 2017;19: 84-6.

doi: 10.1111/bdi.12490

Clemente AS, Diniz BS, Nicolato R, et al. Bipolar disorder prevalence: a systematic review and meta-analysis of the literature. Rev Bras Psiquiatr. 2015;37:155-61.

doi: 10.1590/1516-4446-2012-1693

Joyce K, Thompson A, Marwaha S. Is treat­ment for bipolar disorder more effective earlier in illness course? A comprehensive literature review. Int J Bipolar Disord. 2016;4:19.

doi: 10.1186/s40345-016-0060-6

Nabavi B, Mitchell AJ, Nutt D. A lifetime prevalence of comorbidity between bipolar affective disorder and anxiety disorders: a meta-analysis of 52 interview-based studies of psychiatric population. EBioMedicine. 2015;2:1405-19.

doi: 10.1016/j.ebiom.2015.09.006

Published
2020-02-26
How to Cite
Mysula, Y. I. (2020). PRIMARY EPISODE OF BIPOLAR AFFECTIVE DISORDER. International Journal of Medicine and Medical Research, 5(2), 69-75. https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10895