PRIMARY LARYNGEAL ASPERGILLOSIS IN AN IMMUNOCOMPETENT PATIENT

(case report)

Keywords: primary laryngeal aspergillosis, videostroboscopy

Abstract

Background. Aspergillus is an inherently ubiquitous, weakly pathogenic fungus causing opportunistic infections. It is very rarely localized in the larynx, although laryngeal Aspergillosis may develop in the immunocompromised patients including those with leukaemia and severe aplastic anaemia.

Objective. The aim of the research was to explore the primary laryngeal Aspergillosis in an immunocompetent patient thru a case report.

Methods. A case report of primary laryngeal Aspergillosis in an immunocompetent patient is presented.

Results. A male patient of 40 years old, presenting with chronic worsening hoarseness, was found to have a smooth, white spheroid submucosal growth on left vocal cord with preserved bilateral cord movements on videostroboscopy. Histopathological examination of vocal cord growth revealed squamous epithelium containing septate hyphae with acute angle dichotomous branching pattern consistent with Aspergillus. Voice improved after a four-week course of oral itraconazole 200 mg/day. Post therapy follow up of 24 months was unremarkable.

Conclusions. Primary laryngeal Aspergillosis develops in the immunocompetent patients. Iatrogenic, vocal abuse, occupation and lifestyle factors may be contributory. Optimal diagnosis and management mandates a high index of suspicion.

Author Biographies

K.S. Rajmohan, ARMY COLLEGE OF MEDICAL SCIENCES AND BASE HOSPITAL, NEW DELHI, INDIA

Professor Pathology, Neuropathologist and Head of Department, Army College of Medical Sciences and Base Hospital, New Delhi 110010, India

I. D. Khan, ARMY COLLEGE OF MEDICAL SCIENCES AND BASE HOSPITAL, NEW DELHI, INDIA

Associate Professor, Clinical Microbiology and Infectious Diseases, Army College of Medical Sciences and Base Hospital, New Delhi 110010, India

U. Kapoor, COMMAND HOSPITAL (NC), UDHAMPUR, INDIA

Professor and Head Pathology, Command Hospital (NC), Udhampur 182101, India

S. A. Hashmi, ARMY COLLEGE OF MEDICAL SCIENCES AND BASE HOSPITAL, NEW DELHI, INDIA

Assistant Professor Pathology, Army College of Medical Sciences and Base Hospital, New Delhi 110010, India

R. M. Gupta, ARMED FORCES MEDICAL COLLEGE, PUNE, INDIA

Assistant Professor Pathology, Army College of Medical Sciences and Base Hospital, New Delhi 110010, India

S. Sen, ARMED FORCES MEDICAL COLLEGE, PUNE, INDIA

Professor and Head Microbiology, Armed Forces Medical College, Pune 411040, India

G. L. Nair, Assistant Professor Pathology, Army College of Medical Sciences and Base Hospital, New Delhi 110010, India

Assistant Professor Pathology, Army College of Medical Sciences and Base Hospital, New Delhi 110010, India

K. K. Singh, COMMAND HOSPITAL (NC), UDHAMPUR, INDIA

Assistant Professor Pathology, Army College of Medical Sciences and Base Hospital, New Delhi 110010, India

K. Tandel, ARMY HOSPITAL RESEARCH AND REFERRAL, NEW DELHI, INDIA

Assistant Professor Microbiology, Army Hospital Research and Referral, New Delhi 110010, India

M. Malik, ARMY HOSPITAL RESEARCH AND REFERRAL, NEW DELHI, INDIA

Resident Microbiology, Army Hospital Research and Referral, New Delhi 110010, India

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Published
2020-02-18
How to Cite
Rajmohan, K., Khan, I. D., Kapoor, U., Hashmi, S. A., Gupta, R. M., Sen, S., Nair, G. L., Singh, K. K., Tandel, K., & Malik, M. (2020). PRIMARY LARYNGEAL ASPERGILLOSIS IN AN IMMUNOCOMPETENT PATIENT: (case report). International Journal of Medicine and Medical Research, 5(2), 15-19. https://doi.org/10.11603/ijmmr.2413-6077.2019.2.10456