PHARMACOKINETICS OF THE NEW CEREBROPETECTOR FERRUM BIS(CITRATO)GERMANATE AT THE STAGE OF ITS DISTRIBUTION TO THE ORGANS IN CLOSED HEAD INJURY

  • V. D. Lukianchuk INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE
  • T. A. Bukhtiarova INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE
  • I. I. Seifullina ODESA I. I. MECHNIKOV NATIONAL UNIVERSITY, ODESA, UKRAINE
  • E. M. Polishchuk INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE
  • O. E. Martsinko ODESA I. I. MECHNIKOV NATIONAL UNIVERSITY, ODESA, UKRAINE
  • H. A. Topolnytska INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE
Keywords: ferrum bis(citrato)germanat, closed head injury, pharmacokinetics, brain, liver, kidneys

Abstract

Background. Previous studies showed that new coordinate compound Cerebrogerm (ferrum bis(citrato)germanate) is a promising cerebroprotector.

Objective of the study is a comparative analysis of the central stage of the pharmacokinetics of Cerebrogerm as well as its distribution in vital organs in cases of closed head injury.

Methods. On the experimental original model of closed brain injury in rats the parameters of the central stage of Cerebrogerm pharmacokinetics: the distribution in brain, liver, kidneys, were studied.

Results. It is established that, in cases of closed head injury Cerebrogerm reaches maximum concentration first in the brain (in 3.75 h), then in the kidneys (in 3.92 h), and finally in the liver (in 4.17 h). In this case, the magnitude of the Cmax of the coordinating compound of germanium that is being investigated in different biosubstrates of the rats with closed head injury may be presented in descending order as follows: brain (7.95 mg/L) > liver (6.22 mg/L) > kidneys (1.79 mg/L).

Conclusions. The compound Cerebrogerm studied easily gets through the blood-brain barrier and meets the present requirements for cerebroprotectors and antihypoxants. The attained results allow noting that in the early post-traumatic period of closed head injury, the blood circulation in the kidneys does not change and cannot modify the absorption-elimination processes of xenobiotics. It has been also established that Cerebrogerm is distributed faster in the examined organs in cases of closed head injury. The highest concentration of the drug is present in the brain and the smallest one – in the kidneys.

Author Biographies

V. D. Lukianchuk, INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE

MD, Ph.D., DSc, Professor, Institute of Pharmacology and Toxicology of NAMS of Ukraine, Kyiv, 03680, Ukraine.

ORCID 0000-0002-7734-4739

T. A. Bukhtiarova, INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE

MD, Ph.D., DSc, corresponding member of NAMS of Ukraine, Institute of Pharmacology and Toxicology of NAMS of Ukraine, Kyiv, 03680, Ukraine.

I. I. Seifullina, ODESA I. I. MECHNIKOV NATIONAL UNIVERSITY, ODESA, UKRAINE

Ph.D., DSc, professor, head of the Department of General Chemistry and Polymers, Odesa I.I. Mechnikov National University, Odesa, Ukraine.

E. M. Polishchuk, INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE

MD, Ph.D., Institute of Pharmacology and Toxicology of NAMS of Ukraine, Kyiv, 03680, Ukraine.

O. E. Martsinko, ODESA I. I. MECHNIKOV NATIONAL UNIVERSITY, ODESA, UKRAINE

Ph.D., DSc, professor, Department of General Chemistry and Polymers, Odesa I.I. Mechnikov National University, Odesa, Ukraine.

H. A. Topolnytska, INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE

Institute of Pharmacology and Toxicology of NAMS of Ukraine, Kyiv, 03680, Ukraine.

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Published
2019-07-12
How to Cite
Lukianchuk, V. D., Bukhtiarova, T. A., Seifullina, I. I., Polishchuk, E. M., Martsinko, O. E., & Topolnytska, H. A. (2019). PHARMACOKINETICS OF THE NEW CEREBROPETECTOR FERRUM BIS(CITRATO)GERMANATE AT THE STAGE OF ITS DISTRIBUTION TO THE ORGANS IN CLOSED HEAD INJURY. International Journal of Medicine and Medical Research, 5(1), 58-65. https://doi.org/10.11603/ijmmr.2413-6077.2019.1.10306