PHARMACOKINETICS OF THE NEW CEREBROPETECTOR FERRUM BIS(CITRATO)GERMANATE AT THE STAGE OF ITS DISTRIBUTION TO THE ORGANS IN CLOSED HEAD INJURY
Background. Previous studies showed that new coordinate compound Cerebrogerm (ferrum bis(citrato)germanate) is a promising cerebroprotector.
Objective of the study is a comparative analysis of the central stage of the pharmacokinetics of Cerebrogerm as well as its distribution in vital organs in cases of closed head injury.
Methods. On the experimental original model of closed brain injury in rats the parameters of the central stage of Cerebrogerm pharmacokinetics: the distribution in brain, liver, kidneys, were studied.
Results. It is established that, in cases of closed head injury Cerebrogerm reaches maximum concentration first in the brain (in 3.75 h), then in the kidneys (in 3.92 h), and finally in the liver (in 4.17 h). In this case, the magnitude of the Cmax of the coordinating compound of germanium that is being investigated in different biosubstrates of the rats with closed head injury may be presented in descending order as follows: brain (7.95 mg/L) > liver (6.22 mg/L) > kidneys (1.79 mg/L).
Conclusions. The compound Cerebrogerm studied easily gets through the blood-brain barrier and meets the present requirements for cerebroprotectors and antihypoxants. The attained results allow noting that in the early post-traumatic period of closed head injury, the blood circulation in the kidneys does not change and cannot modify the absorption-elimination processes of xenobiotics. It has been also established that Cerebrogerm is distributed faster in the examined organs in cases of closed head injury. The highest concentration of the drug is present in the brain and the smallest one – in the kidneys.
Shevchuk OV. Experimental ground for α-lipoic acid use in closed head injury. [AutoAbstract]. Kyiv: Institute of Pharmacology and Toxicology of NAMS of Ukraine; 2007. 21 p. [In Ukrainian]
Sadovnik OV. The efficacy of Corvitin in closed head injury. [AutoAbstract]. Kharkiv: National Pharmaceutical University; 2011. 20 p. [In Ukrainian]
Fedorova VS. The efficacy of acetylcysteine in closed head injury. [AutoAbstract]. Kharkiv: National Pharmaceutical University; 2012. 18 p. [In Ukrainian]
Vysotska LV. The search of cerebroprotectors among the new compounds of germanium with bioligands. [AutoAbstract]. Kharkiv: National Pharmaceutical University; 2009. 20 p. [In Ukrainian]
Rysukhina NV. The search of means to correct endotoxicities of posttraumatic origin [AutoAbstract]. Kyiv: Institute of Pharmacology and Toxicology of NAMS of Ukraine; 2010. 20 p. [In Ukrainian]
Lukianchuk VD, Nizhenkovsky OI, Fedorova VS, Kravets DS, Seifullina II, Martsinko OE, Pesaroglo OG. Screening analysis of coordination compounds of germanium in model of closed head injury. Pharmacology and Drug Toxicology. 2012;6:63–8 [In Ukrainian].
Lukianchuk VD, Polishchuk EM, Seifullina II, Rysukhina NV, Martsinko OE, Chebanenko OA. Comparative estimation of cerebroprotective activity of newly synthesized coordination compounds of germanium in the model of closed head injury. Pharmacology and Drug Toxicology. 2014;38(2):36-43 [In Ukrainian].
Lukianchuk VD, Shevchuk OV, Badinov OV, assignee. The animal model of closed head injury; Luhansk State Medical University. Ukraine patent UA 13678. 2006 April 17. 8 p. [In Ukrainian]
Kravets DS. Optimization of calculation of parameters of chemobiokinetics using the EOM software. Ukrainian Medical Almanakh. 2000; 2:90-1 [In Russian].
Golovenko NYa, Lukianchuk VD, Zhuk OV, Zinkovsky VG, Kravets DS, Zhuk MS. Methodical recommendations in computer calculation of pharmacokinetics parameters of drugs. Kyiv: State Scientific-Expertise Center; 1999. 70 p.
Kresiun VI, Vidavska AG, Shemonaeva KF. Extraction-fotometric evaluation of micro amounts of germanium in tissues of experimental animals. Odesa Medical Journal. 2000;62(6):7-11.
Polishchuk EN, Kravets DS. Experimental mathematical analysis of dose regimen of potential cerebroprotector Cerebrogerm. Medical Journal of Western Kazakhstan. 2014; 44(4): 26-31 [In Russian].
Authors who sent their manuscript to International Journal of Medicine and Medical Research agree to the following terms:
1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License CC-BY-NC that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
2. Authors able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).