ОНТОЛОГІЧНА МОДЕЛЬ ПРОЦЕСІВ ПРОГРАМОВАНОЇ КЛІТИННОЇ  ЗАГИБЕЛІ

O. P. Mintser; D. V. Vatlitsov

doi:10.11603/mie.1996-1960.2015.2.4906

Автор(и)

O. P. Mintser Національна медична академія післядипломної освіти імені П. Л. Шупика http://orcid.org/0000-0002-7224-4886
D. V. Vatlitsov Національна медична академія післядипломної освіти імені П. Л. Шупика

DOI:

https://doi.org/10.11603/mie.1996-1960.2015.2.4906

Анотація

Структурною одиницею життя на землі є клітина. Важливим аспектом існування клітини, як одиниці життя, є її здатність до елімінації нежиттєздатних або дефектних одиниць з системи без пошкодження інших одиниць. Проведені дослідження виявили зростання кількості робіт, присвячених системним дослідженням програмованої клітинної загибелі. Виходячи з результатів проведеного аналізу літературних джерел формалізовано схему та описано рівні організації, на яких можливе виникнення «події», яка ініціює каскади, що призводять до настання ПКЗ. Також було виявлено основні напрямки розвитку досліджень, переважна кількість котрих охоплюють рівні вище молекулярної взаємодії, згідно з запропонованою нами онтологічною моделлю програмованої клітинної загибелі. Виявлено біфуркаційну природу проходження сигналу ПКЗ та окреслено роль компонентів, віднесених нами до рівнів нижче молекулярної взаємодії. На основі цих даних запропоновано маркери розвитку та способи управління процесами ПКЗ через контроль концентрації іонів промоутерів та інгібіторів. Результати даного дослідження є підґрунтям для системного вивчення шляхів виникнення, розвитку та управління активного каскаду ПКЗ.

Посилання

Overlapping genes: a new strategy of thermophilic stress tolerance in prokaryotes / D. Saha, A. Panda, S. Podder, Т. C. Ghosh//Extremophiles: Life Under Extreme Conditions. - 2015. - Vol. 19, No. 2. - P. 345-353.

Temperature and ph control on lipid composition of silica sinters from diverse hot springs in the taupo volcanic zone, new Zealand / G. Kaur, B. W. Mountain, M. B. Stott [et al.] / / Extremophiles: Life Under Extreme Conditions. - 2015. -Vol. 19, No. 2.-P. 327-344.

Efficacy in microbial sterilization of pulsed magnetic field treatment: international journal of food engineering / .

Kurtti T. J. Influence of physical factors on the growth of insect cells / T. J. Kurtti, S. P. S. Chaudhary, M. A. Brooks // In Vitro.- 1974.-Vol. 10,No. 3-4.-P. 149-156.

Grahl T. Killing of micro organisms by pulsed electric fields / T. Grahl, H. Markl // Applied Microbiology and Biotechnology. - 1996. - Vol. 45, No. 1-2. - P. 148-157.

Microbial activity at gigapascal pressures / A. Shanna, J. H. Scott, G. D. Cody [et al.] // Science (NewYork, N.Y.). -2002. - Vol. 295, No. 5559. - P. 1514-1516.

Witkin E. M. Time, temperature, and protein synthesis: a study ofultraviolet-inducedmutationinbacteria/E. M. Witkin // Cold Spring Harbor Symposia on Quantitative Biology. -1956.-Vol. 21.-P. 123-140.

Programmed cell death (pcd). apoptosis, autophagic pcd, or others? /W. Bursch,A. Ellinger, C. Gerner [et al.] //Annals ofthe New York Academy of Sciences. - 2000. - Vol. 926. -P. 1-12.

Elmore S. Apoptosis: a review of programmed cell death / S. Elmore // Toxicologic pathology. - 2007. - Vol. 35, No. 4. -P. 495-516.

Mazzarello P. Aunifying concept: the history of cell theory / P. Mazzarello //Nature Cell Biology. -1999. -Vol. l,No. 1. -P. 13-15.

Molecular cell biology/Н. Lodish,A. Berk S. L. Zipursky [et al.]. - W. H. Freeman, 2000. - ISBN 0-7167-3136-3.

Quality assessment of the human genome sequence / J. Schmutz, J. Wheeler, J. Grimwood [et al.] //Nature.-2004. - Vol. 429, No. 6990. - P. 365-368.

Ham D. The sihcon that moves and feels small living things / D. Ham, R. M. Westervelt // IEEE Solid-State Circuits Society Newsletter. - 2007. - Vol. 12, No. 4. - P. 4-9.

Methods for comparing data across differently designed agronomic studies: examples of different meta-analysis methods used to compare relative composition of plant foods grown using organic or conventional production methods and a protocol for a systematic review / K. Brandt, D. Srednicka-Tober, M. Baranski [et al.] // Journal ofAgricultural and Food Chemistry. - 2013. - Vol. 61, No. 30. - P. 7173-7180.

Writing@csu [Електронний ресурс] http:// writing, colostate.edu.

Mello R. A. Collocation analysis: a method for conceptualizing and understanding narrative data /R. A. Mello // QuaUtative research. - 2002. - Vol. 2, No. 2. - P. 231-243.

Мінцер О. П. Щодо межі доцільності використання поняття/ О. П. Мінцер, К. M. Ігрунова//Медична інформатика та інженерія. - 2014. - No. 4. - P. 14—22.

Cosmic ray [Електронний ресурс] https:// en.wikipedia.org/w/index.php?title = Cosmic ray&oldid=650931064.

Ionizing radiation [Електронний ресурс] http:// en.wikipedia.org/w/index.php?title = Ionizing radiation&oldid=653525197.

B. Sc E. R. M. A. Viii. uranium radiation and the electrical conduction produced by it / E. R. M. A. B. Sc // Philosophical Magazine Series 5. - 1899. - Vol. 47, No. 284. - P. 109-163.

STAR Collaboration Observation ofthe antimatter helium-4 nucleus / STAR Collaboration//Nature. - 2011. - Vol. 473, No. 7347.-P. 353-356.

Adriani O. The discovery of geomagnetically trapped cosmic ray antiprotons / O. Adriani, G. C. Barbarino, G. A. Bazilevskaya[et al.] // The Astrophysical Journal. - 2011. -Vol. 736, No. 1.-P.L1.

Hodgkins P. S. The severity of alpha-particle-induced dna damage is revealed by exposure to cell-free extracts / P. S. Hodgkins, P. O'Neil, D. Stevens, M. P. Fairman//Radiation Research. - 1996. - Vol. 146, No. 6. - P. 660-667.

Lehnert В. E. Anew mechanism for dna alterations induced by alpha particles such as those emitted by radon and radon progeny / В. E. Lehnert, E. H. Goodwin // Enviromnental Health Perspectives. - 1997. - Vol. 105 Suppl 5. - P. 10951101.

Feinendegen L. E. Evidence for beneficial low level radiation effects and radiation honnesis / L. E. Feinendegen / /The British Journal ofRadiology. - 2005.-Vol. 78,No. 925. - P. 3-7.

Vaiserman A. M. Radiation honnesis: historical perspective and implications for low-dose cancer risk assessment / A. M. Vaiserman // Dose-Response. - 2010. -Vol. 8,No. 2.-P. 172-191.

Who I ionizing radiation, health effects and protective measures [Електронний ресурс] http://en.wikipedia.Org/w/ index.php?title=Ionizing radiation&oldid=653525197

Ionizing radiation induces apoptotic signal through protein kinase сд (delta) and survival signal through akt and cyclic-nucleotide response element-binding protein (creb) in jurkat t cells / A. Cataldi, V. D. Giacomo, M. Rapino [et al.] // The Biological Bulletin. - 2009. - Vol. 217, No. 2. - P. 202-212.

Watters D. Molecular mechanisms of ionizing radiation-induced apoptosis / D. Watters // Immunology and Cell Biology. - 1999. - Vol. 77, No. 3. - P. 263-271.

Yoon J. Cytosolic irradiation of femtosecond laser induces mitochondria-dependent apoptosis-like cell death via intrinsic reactive oxygen cascades / J. Yoon, S. Ryu, S. Lee, C. Choi / / Scientific Reports. - 2015. - Vol. 5.

Blue light induced apoptosis in rat retina / J. Wu, S. Seregard, B. Spangberg [et al.] // Eye (London, England). - 1999. - Vol. 13 (Pt 4). - P. 577-583.

Light-induced apoptosis in the rat retina in vivo / С. E. Reme, M. Weller, P. Szczesny [et al.] // Degenerative Diseases of the Retina / R. E. Anderson, M. M. LaVail, J. G. Hollyfield. - Springer US, 1995. - P. 19-25.

Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and mpp+-induced neurotoxicity / H. L. Liang, H. T. Whelan, J. T. Eells, M. T. Wong-Riley // Neuroscience. - 2008. - Vol. 153, No. 4. - P. 963-974.

Jantschitsch C. Infrared radiation does not enhance the frequency of ultraviolet radiation-induced skin tumors, but their growth behaviour in mice / C. Jantschitsch, M. Weichenthal, A. Maeda [et al.] // Experimental Dermatology. - 2011. - Vol. 20, No. 4. - P. 346-350.

Vojisavljevic V. Low intensity microwave radiation as modulator of the 1-lactate dehydrogenase activity / V. Vojisavljevic, E. Pirogova, I. Cosic//Medical & Biological Engineering & Computing. -2011. - Vol. 49, No. 7. - P. 793799.

Local exposure of849mhzand 1763 mhzradiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain / T.-H. Kim, T.-Q. Huang, J.-J. Jang [et al.] // Experimental & Molecular Medicine. - 2008. -Vol. 40, No. 3,-P. 294-303.

Xihai Li H. Y Millimeter wave radiation induces apoptosis via affecting the ratio of bax/bcl-2 in swl353 human chondrosarcoma cells / H. Y. Xihai Li // Oncology reports. -2011. - Vol. 27, No. 3. - P. 664-72.

Teppone M. Extremely high-frequency therapy in oncology / M. Teppone, R. Avakyan // Journal of Alternative and Complementary Medicine (New York, N.Y.). - 2010. -Vol. 16, No. 11.-P. 1211-1216.

Enhancement of ultrasound-induced apoptosis and cell lysis by echo-contrast agents / L. B. Feril, T. Kondo, Q.-L. Zhao [et al.] // Ultrasound in Medicine & Biology. - 2003. -Vol. 29,No. 2.-P. 331-337.

Feng Y Bioeffects of low-intensity ultrasound in vitro: apoptosis, protein profile alteration, and potential molecular mechanism/Y. Feng, Z. Tian, M. Wan// Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine. - 2010. - Vol. 29, No. 6. - P. 963974.

Tang W. Potential mechanism in sonodynamic therapy and focused ultrasound induced apoptosis in sarcoma 180 cells in vitro / W. Tang, Q. Liu, X. Wang [et al.] // Ultrasonics. -2009. - Vol. 49, No. 8. - P. 786-793.

Beebe S. J. Non-ionizing radiation generated by nanosecond pulsed electric fields (nspefs) induce apoptosis in cancer in vivo / S. J. Beebe, X. Chen, J. Kolb, К. H. Schoenbach. - 2008. - 1-1 p.

Molecular biology of the cell / B. Alberts, A. Johnson, J. Lewis [et al.]. - Garland Science, 2002. - ISBN 0-81533218-1; 0-8153-4072-9.

Essential cell biology, fourth edition/B. Alberts, D. Bray, K. Hopkin [et al.]. - Garland Science, 2013. - ISBN 9781317806271.

Clausen M. J. V. Sodium/potassium homeostasis in the cell/M. J. V. Clausen, H. Poulsen//Metallomics and the Cell / L. Band. - Springer Netherlands, 2013. - P. 41-67.

Changes in intracellular sodium, chlorine, and potassium concentrations in staurosporine-induced apoptosis / F. Arrebola, S. Zabiti, F. J. Canizares [et al.] // Journal of Cellular Physiology. - 2005. - Vol. 204, No. 2. - P. 500-507.

Amethod for estimating intracellular sodium concentration and extracellular volume fraction in brain in vivo using sodium magnetic resonance imaging / G. Madelin, R. Kline, R. Walvick, R. R. Regatte // Scientific Reports. - 2014. -Vol. 4.

Geleijnse J. M. Impact of dietary and lifestyle factors on the prevalence of hypertension in western populations / J. M. Geleijnse, F. J. Кок, D. E. Grobbee// European Journal of Public Health. - 2004. - Vol. 14, No. 3. - P. 235-239.

Hellgren M. A comparison between two prokaryotic potassium channels (kirbacl.l and kcsa) in a molecular dynamics (md) simulation study / M. Hellgren, L. Sandberg, O. Edhohn//Biophysical Chemistry.-2006.-Vol. 120, No. 1. - P. 1-9.

Romani A. M. P. Magnesium in health and disease / A. M. P. Romani//Interrelations between Essential Metal Ions and Human Diseases / A. Sigel, H. Sigel, R. К. O. Sigel. -Springer Netherlands, 2013. - P. 49-79.

Spectrochemical analysis of sodium, potassium, calcium, magnesium, copper, and zinc in normal human erythrocytes / L. S. Valberg, J. M. Holt, E. Paulson, J. Szivek//The Journal of Clinical Investigation. - 1965. - Vol. 44. - P. 379-389.

Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin Ь6. i. attention deficit hyperactivity disorders / M. Mousain-Bosc, M. Roche, A. Polge [et al.] // Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium. - 2006. - Vol. 19, No. 1. - P. 46-52.

Wu W. Surface charge-mediated effects of mg on к flux across the chloroplast envelope are associated with regulation of stromal ph and photosynthesis / W. Wu, J. Peters, G. A. Berkowitz // Plant Physiology. -1991. - Vol. 97, No. 2. -P. 580-587.

Berridge M. J. Calcium signalling: dynamics, homeostasis and remodelling / M. J. Berridge, M. D. Bootman, H. L. Roderick // Nature Reviews Molecular Cell Biology. -2003. - Vol. 4, No. 7. - P. 517-529.

Calcium-dependent intracellular signal pathways in primary cultured adipocytes and ank3 gene variation in patients with bipolar disorder and healthy controls / A. Hayashi, K. Le Gal, K. Sodersten [et al.] // Molecular Psychiatry. -2014.

Pml regulates apoptosis at endoplasmic reticulum by modulating calcium release / C. Giorgi, K. Ito, H.-K. Lin [et al.]//Science.-2010.-Vol. 330,No. 6008.-P. 1247-1251.

Calcium and apoptosis: er-mitochondria Ca2+ transfer in the control of apoptosis / P. Pinton, C. Giorgi, R. Siviero [et al.] // Oncogene. - 2008. - Vol. 27, No. 50. - P. 6407-6418.

Calcium-activated raf/mek/erk signaling pathway mediates p53-dependent apoptosis and is abrogated by ab-crystallin through inhibition of ras activation / D. W.-C. Li, J.-P. Liu, Y.-W. Mao [et al.] // Molecular biology of the cell. - 2005. -Vol. 16, No. 9. - P. 4437-4453.

Intracellular calcium homeostasis and signaling / M. Brini, T. Cali, D. Ottolini, E. Carafoli // Metallomics and the Cell / L. Band. - Springer Netherlands, 2013. - P. 119-168.

Maret W. Analyzing free zinc(ii) ion concentrations in cell biology with fluorescent chelating molecules / W. Maret //Metallomics: IntegratedBiometal Science.-2015.-Vol. 7, No. 2.-P. 202-211.

Plum L. M. The essential toxin: impact of zinc on human health/L. M. Plum, L. Rink, H. Haase//International Journal of Environmental Research and PubUc Health. - 2010. - Vol. 7, No. 4.-P. 1342-1365.

Maret W. Zinc and human disease / W. Maret // Interrelations between Essential Metal Ions and Human Diseases / A. Sigel, H. Sigel, R. К. O. Sigel. - Springer Netherlands, 2013. - P. 389-414.

Prasad A. S. Zinc in human health: effect of zinc on immune cells / A. S. Prasad // Molecular Medicine (Cambridge, Mass.). - 2008. - Vol. 14, No. 5-6. - P. 353357.

Potential roles ofzinc in the pathophysiology and treatment of major depressive disorder / W. Swardfager, N. Herrmann, R. S. Mclntyre [et al.] // Neuroscience and Biobehavioral Reviews. - 2013. - Vol. 37, No. 5. - P. 911-929.

Wackett L. P. Microbial genomics and the periodic table / L. P. Wackett, A. G. Dodge, L. B. M. Ellis // Applied and Environmental Microbiology. - 2004. - Vol. 70, No. 2. -P. 647-655.

Hoehler T. M. Biological energy requirements as quantitative boundary conditions for life in the subsurface / T. M. Hoehler//Geobiology.-2004.-Vol. 2,No. 4.-P. 205215.

Carugo O. Buried chloride stereochemistry in the protein data bank / O. Carugo // BMC Structural Biology. - 2014. -Vol. 14,No. l.-P. 19.

Bonar P. T. Plasma membrane cl-/hco3-exchangers: structure, mechanism and physiology/P. T. Bonar, J. R. Casey // Channels. - 2008. - Vol. 2, No. 5. - P. 337-345.

Three dimensional structure of porcine pancreatic alpha-amylase at 2.9 a resolution, role of calcium in structure and activity / G. Buisson, E. Duee, R. Haser, F. Payan//TheEMBOjournal. - 1987.-Vol. 6, No. 13,-P. 3909-3916.

Bergwitz C. Phosphate sensing/C. Bergwitz, H. Juppner //Advances in chronic kidney disease.-2011.-Vol. 18, No. 2. -P. 132-144.

A study of intracellular orthophosphate concentration in human muscle and erythrocytes by Зір nuclear magnetic resonance spectroscopy and selective chemical assay / A. Bevington, К. I. Mundy, A. J. Yates [et al.] // Clinical Science (London, England: 1979). - 1986. - Vol. 71, No. 6. -P. 729-735.

Marshall W. J. Clinical biochemistry: metabolic and clinical aspects / W. J. Marshall, S. K. Bangert. - Elsevier Health Sciences, 2008. - ISBN 0443101868.

Schmittner K.-E. Micro-enviromnental controls on biomineralization: superficial processes of apatite and calcite precipitation in quaternary soils, roussillon, fiance / K.-E. Schmittner, P. Giresse // Sedimentology. - 1999. -Vol. 46, No. 3,- P. 463л176.

Hirsch А. К. H. Phosphate recognition in structural biology / А. К. H. Hirsch, F. R. Fischer, F. Diederich // Angewandte Chemie (International Ed. in English). - 2007. -Vol. 46, No. 3.-P. 338-352.

Kaupp U. B. Cell biology, a universal bicarbonate sensor /U. B. Kaupp, I. Weyand // Science (NewYork NY.). - 2000. -Vol. 289, No. 5479. - P. 559-560.

Bortner C. D. A necessary role for cell shrinkage in apoptosis / C. D. Bortner, J. A. Cidlowski // Biochemical Pharmacology. - 1998. - Vol. 56, No. 12. - P. 1549-1559.

Lagadic-Gossmann D. Alterations of intracellular ph homeostasis in apoptosis: origins and roles / D. Lagadic-Gossmann, L. Hue, V. Lecureur // Cell Death & Differentiation. - 2004. - Vol. 11, No. 9. - P. 953-961.

Yu S. P. Ion homeostasis and apoptosis / S. P. Yu, L. M. T. Canzoniero, D. W. Choi // Current Opinion in Cell Biology. -2001. - Vol. 13, No. 4. - P. 405-411.

Stitch: chemical association networks [Електронний ресурс] http://stitch.embl.de/cgi/show input page.pl? Userld=JVpPznnqaB sj &sessionId=7Rj 9WLk964bn .

Ho S. N. Intracellular water homeostasis and the mammalian cellular osmotic stress response / S. N. Ho // Journal of Cellular Physiology. - 2006. - Vol. 206, No. 1. -P. 9-15.

Balasubramanian S. K. Membrane hydration correlates to cellular biophysics during freezing in mammalian cells / S. K. Balasubramanian, W. F. Wolkers, J. C. Bischof // Biochimica et Biophysica Acta (BBA) - Biomembranes. -2009. - Vol. 1788, No. 5. - P. 945-953.

Cooper G. M. The cell / G. M. Cooper. - Sinauer Associates, 2000. - ISBN 0-87893-106-6.

Apoptosis and necrosis: intracellular atp level as a detenninant for cell death modes / Published online: 10 July 1997; I doi:10.1038/sj.cdd.4400262.- 1997.-Vol. 4, No. 6.

Cells die with increased cytosolic atp during apoptosis: a bioluminescence study with intracellular luciferase / M. V. Zamaraeva, R. Z. Sabirov, E. Maeno [et al.] // Cell Death & Differentiation.-2005.-Vol. 12, No. 11.-P. 1390-1397.

Dwyer D. J. Identification and characterization of programmed cell death markers in bacterial models / D. J. Dwyer, J. A. Winkler // Methods in Molecular Biology (Clifton, N.J.).-2013.-Vol. 1004.-P. 145-159.

Kristiansen M. Programmed cell death during neuronal development: the sympathetic neuron model/М. Kristiansen, J. Ham // Cell Death & Differentiation. - 2014. - Vol. 21, No. 7.-P. 1025-1035.

String: functional protein association networks [Електронний ресурс] http://string-db.org/newstring cgi/show input j>age.pl?UserId=BPssjFi03UYV&sessionId =7YqlbvWJPD4A.

Lavin M. F. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer / M. F. Lavin // Nature Reviews Molecular Cell Biology. - 2008. - Vol. 9, No. 10. -P. 759-769.

The contribution of apoptosis-inducing factor, caspase-activated dnase, and inhibitor of caspase-activated dnase to the nuclear phenotype and dna degradation during apoptosis / V. J. Yuste, I. Sanchez-Lopez, C. Sole [et al.] // Journal of Biological Chemistry.-2005.-Vol. 280, No. 42.-P. 3567035683.

Sperelakis N. Cell physiology source book: essentials of membrane biophysics / N. Sperelakis. - Elsevier, 2012. -ISBN 9780080574554.

Chen G. Tnf-rl signaling: a beautiful pathway / G. Chen, D. V. Goeddel // Science (NewYork NY.). - 2002. - Vol. 296, No. 5573.-P. 1634-1635.

Ihnatko R. Tnf signaling: early events and phosphorylation /R. Ihnatko, M. Kubes// General Physiology and Biophysics. - 2007. - Vol. 26, No. 3. - P. 159-167.

Mutations in apoptosis genes: a pathogenetic factor for human disease / L. Mullauer, P. Gruber, D. Sebinger [et al.] / / Mutation Research/Reviews in Mutation Research. - 2001. -Vol.488, No. 3.-P. 211-231.

Koonin E. V. The ancient virus world and evolution of cells / E. V. Koonin, T. G. Senkevich, V. V. Dolja // Biology Direct. - 2006. - Vol. 1. - P. 29.

Human genome project [Електронний ресурс] http:// en.wikipedia.org/w/index.php?title=Human Genome Project&oldid=653998083.

Ndozangue-Touriguine O. Cytoskeleton and apoptosis / O. Ndozangue-Touriguine, J. Hamelin, J. Breard // Biochemical Pharmacology. - 2008. - Vol. 76, No. 1. -P. 11-18.

Kong Q. The centrosome-centered cell-brain in apoptosis /Q. Kong//Medical Hypotheses.-2003.-Vol. 61,No. 1,-P. 126-132.

GenescaM. Actin cytoskeleton derangement induces apoptosis in renal ischemia/reperfusion/M. Genesca,A. Sola, G. Hotter // Apoptosis: An International Journal on Programmed Cell Death. - 2006. - Vol. 11, No. 4. - P. 563571.

Lecoeur H. Nuclear apoptosis detection by flow cytometry: influence of endogenous endonucleases / H. Lecoeur // Experimental Cell Research.-2002.-Vol. 277, No. l.-P. 114.

Fadeel B. Plasma membrane alterations during apoptosis: role in corpse clearance / B. Fadeel // Antioxidants & Redox Signaling. - 2004. - Vol. 6, No. 2. - P. 269-275.

Regulation of apoptosis by endoplasmic reticulum pathways / D. G. Breckenridge, M. Germain, J. P. Mathai [et al.] //0ncogene.-2003.-Vol. 22, No. 53.-P. 8608-8618.

Wang C. The role of mitochondria in apoptosis* / C. Wang, R. J. Youle //Annual Review of Genetics. - 2009. -Vol. 43.-P. 95-118.

Hicks S. W. Golgi structure in stress sensing and apoptosis / S. W. Hicks, С. E. Machamer // Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. - 2005. -Vol. 1744, No. 3. - P. 406-414.

Nuclear apoptosis induced by isolated mitochondria / Z. F. Jiang, Y. Zhao, X. Hong, Z. H. Zhai // Cell Research. -2000.-Vol. 10, No. 3,-P. 221-232.

Intercellular bridges and apoptosis in clones of male germ cells / G. Hamer, H. L. Roepers-Gajadien, I. S. Gademan [et al.] // International Journal of Andrology. - 2003. - Vol. 26, No. 6.-P. 348-353.

Wang X. Transfer of mitochondria via tunneling nanotubes rescues apoptotic pcl2 cells / X. Wang, H.-H. Gerdes//Cell Death & Differentiation.-2015-P. 1-11.