STUDY OF ULTRASTRUCTURE PROFILE OF FOLLICULAR THYROCYTES' TRANSPORT CAPABILITIES BY MEANS OF CORRELATION ANALYSIS
DOI:
https://doi.org/10.11603/mie.1996-1960.2021.3-4.12638Abstract
Background. The use of mathematical methods to study the morpho-functional features of follicular thyrocytes in the correction of alimentary iodine deficiency is an urgent task of cytophysiology. The purpose of this work is to study the peculiarities of the relationship between the ultrastructures of follicular thyrocytes in the transport direction of their activity (basal cytoplasmic membrane, pericapillary space, microcapillary bed, endotheliocytes) when taking organic and inorganic iodine.
Material and methods. The object of the study were electronograms of the thyroid glands of white male rats, whose iodine deficiency in the diet was corrected histologically with the minimum effective dose of organic and inorganic iodine. The research methods were linguistic description of electronograms. Method of semi-quantitative analysis of electronograms, Method on specifying the profiles of special capabilities of hormone-poietic cells, correlation analysis with the construction of correlation portraits.
Results. It is established that the linguistic (descriptive) characteristic of the thyrocyte ultrastructures' state is informative, but does not allow to clarify the features of their mutual influence and interdependencies. Analysis of correlation portraits revealed that in the conditions of alimentary iodine deficiency the state of the microcapillary bed is disturbed, while the intake of organic and inorganic iodine improves its morpho-functional state.
Conclusions. With alimentary iodine deficiency, the improvement of hemocirculation in the microcapillary bed of the thyroid gland by iodine of organic and inorganic chemical nature is provided by various ultrastructural components of the transport capability profile of follicular thyrocytes: when taking organic iodine, it is manifested by optimization of correlations between follicular thyrocytes with significant folding of their cytoplasmic basal membranes and unchanged endotheliocytes, when taking inorganic iodine — by correlations between the pericapillary space of moderate width and hypertrophied endotheliocytes.
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