HEART-DERIVED HORMONES: BIOMEDICAL INTERACTION OF DISTANT, PARACRINE AND AUTOCRINE ACTION
DOI:
https://doi.org/10.11603/mie.1996-1960.2020.3.11603Abstract
Background. The heart plays a central role in the circulatory system and provides the body with the necessary oxygen, nutrients and protein growth factors. However, today it can synthesize and make signaling molecules for communication with distant target organs. The study of long-known and recently discovered heart hormones promotes this mechanism of their action in coordination with the function of the heart and the biology of target organs. The purpose of the study was to conceptualization of the «endocrine heart» paradigm.
Materials and methods. Results. The paper considers the biochemistry, signaling, function, regulation and clinical significance of representative hormones of cardiac origin with an emphasis on their participation in the development of complex biomedical processes in normal and cardiovascular pathology. The substantiation of the «endocrine heart» paradigm provided a transition from the classical notion of the heart as an organ functioning exclusively as a blood pump to a self-regulating system in the sense of loading in the humoral plan. The study of hormones of cardiac origin revealed their common functional features and emphasize the presence of a hormone-dependent mechanism that the heart uses to communicate with other target organs that control cardiovascular function.
Conclusions. It is emphasized that regardless of the main place of hormones production (heart, other organs), the above-mentioned polypeptide hormones function synergistically, together contribute to the regulation of cardiovascular hemodynamic, affecting vascular tone, autonomic nervous system and normal heart rate and pathology.
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