PECULIARITIES OF THE FULLERENE-HALOGEN LIGHT INFLUENCE ON INFLAMMATORY PAIN, DEPENDING ON CHARACTERISTICS OF THE LIGHT FLUX
DOI:
https://doi.org/10.11603/mie.1996-1960.2020.2.11172Keywords:
polarized polychromatic light, Bioptron-MedAll device, pain, formalin test,, analgesia, fullerene, fullerene modified lightAbstract
Background. The effect of halogen polarized light transformed by fullerene on the locus of pain or acupuncture analgesic point causes analgesic effect. Earlier this was proved by us in animals on the formalin model of pain. This study focuses on characteristics of analgesic reactions of animals under the influence of different wavelength ranges of halogen and fullerene light and to identify the contribution of fullerene component in reducing inflammatory pain depending on the spectrum, power density and illuminance.
Materials and methods. The experiments were performed on mice with an artificially created locus of inflammatory somatic pain (formalin test). The light source was Bioptron-MedAll device equipped with a halogen lamp. In separate series (80 animals in total) we studied the effect of light transmitted through fullerene filters (based on CR39 or PMMA) on the pain intensity and non-painful behavioral reactions when it was applied to the pain locus or to the acupoint (AP) E-36. Analgesic effects were compared with data obtained under the action of polychromatic (480+ nm and 320+ nm) light or 3 placebo light options, taking into account physical characteristics of the filters.
Results. It was found that fullerene light gave the best analgesic effect regardless of the type of filter substance (PMMA or CR39). When fullerene light (CR39 filter) was applied to the pain locus, analgesia was 34.3 %. An analgesic reaction was also detected during its action on the AP E-36 — 32.6 %, while the halogen polychromatic light was weaker (16.2 %). The light passing through the fullerene+PMMA filter when applied to the pain locus alleviated pain by 29.8 %. Polychromatic light application produced analgesia of 480+ nm was 23.2 %, and 320+ nm — 14.4 %. All placebo variants were less effective, although analgesia also occurred: 25.3 % (CR39 fullerene free), 24.9 % (PMMA fullerene free), and 27.7 % (color copy of fullerene filter spectrum).
Conclusion. The biological effectiveness of the studied light variants, estimated by the intensity of pain syndrome, correlated mostly with the power density and the wavelength range of light. Fullerene filters convert PL almost in the same way, with a similar analgesic result, but the biological effect of fullerene+CR39 light is more noticeable. Fullerene modified light, compared to halogen, has the greatest analgesic efficacy against formalin-induced pain. This result is achieved by the sorption of frequencies of the blue part of the spectrum by fullerene and depression of the power of the visible spectrum as a whole.
References
Maegawa, Y., Itoh, T., Hosokawa, T., Yaegashi, K., Nishi, M. (2007). «Effects of Near-Infrared Low-Level Laser Irradiation on Microcirculation. Lasers Surg. Med. 27 (5): 427-37.
Hakguder, A., Birtane, M., Gurcan, S., Kokino, S., Turan, F. (2003). Efficacy of Low Level Laser Therapy in Myofascial Pain Syndrome: An Algometric and Thermographic Evaluation. Lasers Surg. Med. 33 (5):339-43.
Gur, A., Sarac, A., Cevik, R., Altindag, O., and Sapac, S. (2004). Efficacy of 904 NM Gallium Arsenide Low Level Laser Therapy in the Management of Chronic Myofascial Pain in the Neck: A Double-Blind and Randomize-Controlled Trial. Lasers Surg. Med. 35 (3): 229-35.
Ilbuldu, E., Cakmak, A., Disci, R., Aydin, R. (2004). Comparison of Laser, Dry Needling, and Placebo Laser Treatments in Myofascial Pain Syndrome. Photomed. Laser Surg. 22 (4): 306-11.
Schaffer, M., Bonel, H., Spoka, R., Schaffer, P., Busch, M., Reiser, M., and Duhmke, E. (2000). Effects of 780 nm Diode Laser Irradiation on Blood Microcirculation: Preliminary Findings on Time-Dependent T1-Weighted Contrast-Enhanced Magnetic Resonance Imaging (MRI). J. Photochem. Photobiol. B. 54 (1): 55-60.
Fenyo, M. (1984). Theoretical and Experimental Basis of Biostimulation. Optics Laser Technol. 16: 209-15.
Limansky, Y., Gulyar, S., Tamarova, Z. (2009). BIOPTRON-Analgesia: 10. The Participation of the Opioidergic System in the Analgesic Effect of Polarized Light on the Analgesic Acupuncture Point. In Anthology of Light Therapy. Medical Bioptron Technologie. Kyiv: Bogomoletz Institute of Physiology at the National Academy of Sciences of Ukraine, 266-75. [In Russian].
Gulyar, S., Limansky, Y., Tamarova, Z. (1999). Analgesic effects of Bioptron PILER light. J. of Practical Doctor. (4): 21-3. [In Russian].
Limansky, Y., Tamarova, Z., Bidrov, E., Kolbun, N. (1999). Suppression of Nociceptive Responses in Mice by Low-Intensity Microwave Exposure on Acupuncture Points. Neurophysiology 31 (4): 290-4. [In Russian].
Limansky, Y., Tamarova, Z., Gulyar, S., Bidrov, E. (2000). Study of Analgesic Effect of Polarized Light on Acupuncture Points. Fiziol. J. 46 (6): 105-11. [In Ukrainian].
Limansky, Y., Tamarova, Z., Gulyar, S. (2003). Suppression of Visceral Pain by Action of the Low Intensity Polarized Light on Antinociceptive Points of Acupuncture. Fiziol. J. 49 (5): 43-51. [In Ukrainian].
Limansky, Y., Tamarova, Z., Gulyar, S. (2006). Suppression of Pain by Exposure of Acupuncture Points to Polarized Light. Pain Res. Manag. 11 (1): 49-57.
Gulyar, S., Limansky, Y., Tamarova, Z. (2006). Suppression of Pain by Influence of Bioptron-Polarized Lighton Acupoints. European J. Pain. 10: S212.
Limansky, Y., Tamarova, Z., Gulyar, S. (2008). Suppression of Visceral Pain by Exposure of Acupuncture Points to Low-Intensive Polarized Light. Abstracts of the 12th World Congresson Pain. August 17-22. Glasgow, Scotland, UK. Pres. PT 338.
Tamarova, Z., Limansky, Y., Gulyar, S. (2009). Antinociceptive Effects of Color Polarized Light in Animal with FormalinTest. Fiziol. J. 55 (3): 81-93. [In Ukrainian].
Limansky, Y., Gulyar, S., Tamarova, Z. (2009). BIOPTRON-Analgesia: 12. Role of Color in Tonic Pain Suppression. In Anthology of Light Therapy. Medical BIOPTRON Technologies. Kyiv: Bogomoletz Institute of Physiology at the National Academy of Sciences of Ukraine, 722-31. [In Russian].
Pantyo, V. V., Koval, G. M., Pantyo, V. I., Gulyar, S. A. (2017). Effect of LED radiation of different wavelengths on the growth rate of Staphylococcus aureus. ScienceRise: Biological Science, 7 (4): 16-20; 43-45. [In Ukrainian].
R. F., Curl Jr., Sir H., Kroto, R. E., Smalley (2014). The Nobel Prize in Chemistry 1996. Nobelprize. org. Nobel Media AB. Web. 31 Aug 2017. Available from: http:ІІwww.nobelprize.orgІnobel_prizesІchemistryІ laureates/1996/.
Koruga, D. (2017). Hyperpolarized Light: Fundamentals of Nano Medical Photonics. Belgrade: Zepter World Book, 1-306. [In Serbian and in English].
Gulyar. S., Tamarova, Z. (2017). Modification of Polychromatic Linear Polarized Light by Nanophotonic Fullerene and Graphene Filter Creates a New Therapeutic Opportunities. Journal of US-China Medical Science, 14 (5), 173-191.
Gulyar, S., Tamarova, Z. (2017). Anti-Pain and Sedative Action of Polychromatic Polarized Light which Passed Through Nanomodification by Carbon Nanofilters. Proc. of the XLVII International Scientific and Practical Conference Proceedings of Academic Science, Oct. 1214, 2017, Kyiv: 95-97. [In Russian].
Kavaliers, M., Hirst, M. (1983). Daily Rhythms of Analgesia in Mace: Effects of Age and Photoperiod. Brain Res. 279 (1-2): 387-93.
Dubuisson, D., Dennis, S. (1977). The Formalin Test: A Quantitative Study of the Analgesic Effects of Morphine, Meperidine and Brain Stem Stimulation in Rats and Cats. Pain 4 (2): 161-74.
Hunskaar, S., Hole, K. (1987). The Formalin Test in Mice: Dissociation between Inflammatory and nonInflammatory Pain. Pain 30 (1): 103-14.
Sugimoto, M., Kuraishi, Y., Satoh, M., Takagi, H. (1986). Involvement of Medullary Opioid Peptidergic and Spinal Noradrenergic Systems in the Regulation of Formalin-Induced Persistent Pain. Neuropharmacology 25 (5): 481-5.
Tamarova, Z. A., Limansky, Yu. P., Gulyar, S. A. (2009). Antinociceptive effects of color polarized light in animal formalin test model. Fiziol. J., 55 (3): 81-93.
Gulyar, S. A., Kosakovskyi, A. L. eds. (2011). Bioptron-PILER-Light Application in Medicine (2nd ed.). Kyiv: Bogomoletz Institute of Physiology at the National Academy of Sciences of Ukraine, 1-256. [In Russian].
Gulyar, S., Tamarova, Z. (2015). Comparative evaluation of the analgesic effect of red polarized radiation from halogen and LED sources Photobiology and experimental photomedicine,12 (1-2): 42-48.
Gulyar, S. A., Limansky, Yu. P., Tamarova, Z. A. (2004). Pain and color. Treatment of pain syndromes by polarized light. Kyiv-Donetsk: Biosvet. 1-122. [In Russian].
Gulyar, S. A., Limansky, Yu. P., Tamarova, Z. A. (2007). Pain color therapy. Treatment of pain syndromes by polarized light (2nd Ed). Kyiv: Ukr. Nat. Acad. Sci, 1-128. [In Russian].
Gulyar, S. A., Filimonova, N. B., Makarchuk, M. Yu., Kryvdiuk, Y. N. (2019). Ocular Influence of Nano-Modified Fullerene Light: 1. Activity of Default Networks of the Human Brain. Journal of US-China Medical Science, 16 (2): 1-15.
Gulyar, S. A., Filimonova, N. B., Makarchuk, M. Yu., Krivdiuk, Y. N. (2019). Ocular Influence of Nano-Modified Fullerene Light: 2. Time correlation of the choice and simple sensorimotor reactions that determine blinding compensation of the driver. Journal of US-China Medical Science, 16 (3): 105-115.
Gulyar, S. A., Tamarova, Z. A., Kirilenko, Ye. K. (2019). Ocular Influence of Nano-Modified Fullerene Light: 3. Speed and Quality of Visual Information Processing in Man. Journal of US-China Medical Science, 16 (3): 116-133.
Gulyar, S. A., Tamarova, Z. A., Kirilenko, Ye. K., Filimonova, N. B., Makarchuk, N. Yu., Krivdiuk, Yu. N. (2019). Physiological effects of light with spatial structure converted by fullerene. Medical Informatics and Engineering, 45 (1): 39-58. [In Russian].
Limansky, Y. P., Gulyar, S. A., Tamarova, Z. A. (2009). Bioptron-induced analgesia: І0. involvement of opioid-ergic system in analgetic effect of polarized light on antinociceptive acupuncture point. Anthology of light therapy. Medical BIOPTRON technologies. Kyiv: Bogomoletz Institute of Physiology at the National Academy of Sciences of Ukraine: 266- 275. [In Russian].
Limansky, Y., Gulyar, S., Tamarova, Z. (2009). BIOPTRON-analgesia: І2. Role of color in tonic pain suppression. Anthology of light therapy. Medical BIOPTRON technologies. Kyiv: Bogomoletz Institute of Physiology at the National Academy of Sciences of Ukraine: 722-731. [In Russian].
Limansky, Y., Gulyar, S., Tamarova, Z. (2009). BIOPTRON-analgesia: ІІ. Comparative investigation of red polarized light analgesic action while application at pain locus, analgesic acupuncture point and the whole animal. Anthology of light therapy. Medical BIOPTRON technologies. Kyiv: Bogomoletz Institute of Physiology
at the National Academy of Sciences of Ukraine; 716721. [In Russian].
Gulyar, S. A., Limansky, Y. P. (2003). Functional system of the organism electromagnetic balance regulation: mechanisms of primary reception of electromagnetic waves of optical range. Phyziol. J., 49 (2): 35-44. [In Ukrainian].
Gulyar, S. A. (20І8). Accents of the Human Body Electromagnetic Balance Regulation System. Photobiology and Photomedicine, 24: 52-68.
Hensel, H., Kenshalo, D. R. (І969). Warm receptors in the nasal region of cats. J Physiol, 204: 99 -ІІ2.
Tamarova, Z. A., Limansky, Yu. P., Gulyar, S. A., Yanenko, O. P., Kutsenko, V. P., Matsybura, A. P. (2009). Additional microwave irradiation of Bioptron devices in millimeter range. Anthology of light therapy. Medical BIOPTRON technologies. Kyiv: Bogomoletz Institute of Physiology at the National Academy of Sciences of Ukraine, 899-905. [In Russian].
Downloads
Published
How to Cite
Issue
Section
License
Journal Medical Informatics and Engineering allows the author(s) to hold the copyright without registration
The majority of Medical Informatics and Engineering Open Access journals publish open access articles under the terms of the Creative Commons Attribution (CC BY) License which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The remaining journals offer a choice of licenses.
This journal is available through Creative Commons (CC) License CC-BY 4.0
