THE NETWORK BASIS OF THE FUNCTIONING OF BIOLOGICAL OSCILLATORS — OSCILLATOR CIRCUIT TRIGGERS IN CELLS AND CELL-FREE SYSTEMS. ANALYTICAL REVIEW
DOI:
https://doi.org/10.11603/mie.1996-1960.2019.1.10110Keywords:
biological oscillators complicated network, systemic biology, synthetic biology, fundamental mechanisms, triggersAbstract
Background. An analytical study examines experimental and theoretical studies in the field of quantitative system analysis of the role of biological oscillators — oscillatory circuit triggers in cells and cell-free systems. Biological oscillators control bursts of neuronal activity, cell cycles, sleep and wake patterns, as well as many other important processes in living systems. It is assumed that quantitative studies of the functioning of biological oscillators will help in the prevention and treatment of many human diseases.
Results. Over the past decades, the development of methods in the field of systemic and synthetic biology has made it possible to outline ways to decipher the fundamental mechanisms underlying the functioning of these oscillators. It is shown that systemic and synthetic biology acquires significant importance in further determining the mechanisms of functioning of biological oscillators. Although research on the functioning of biological oscillators has made some progress in identifying features of the functioning of natural and artificial oscillators that increase the reliability and quality of rhythms control of biological reactions, however, the role of many other minor modifications remains poorly understood. To understand it, further theoretical and experimental research is needed.
Conclusions. The role of developing tools and methods of bioinformatics becomes extremely important in promoting systemic and synthetic biology, and the already established quantitative approaches of systemic and synthetic biology in a transdisciplinary approach involving modern techniques of other fields of knowledge.
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