ABOUT THE PARADIGM OF COMBINING SYSTEMIC BIOLOGY AND SYSTEMIC MEDICINE REPRESENTATIONS FOR FORMING A NEW LOOK AT DIAGNOSTICS AND TREATMENT OF ISCHEMIC HEART DISEASE

Authors

  • O. P. Mintser Shupyk National Medical Academy of Postgraduate Education
  • L. Yu. Babintseva Shupyk National Medical Academy of Postgraduate Education
  • N. V. Kharchenko Shupyk National Medical Academy of Postgraduate Education

DOI:

https://doi.org/10.11603/mie.1996-1960.2018.1.8886

Keywords:

systemic biology and systemic medicine representations, diagnostics and treatment of coronary heart disease, intellectual bridge, trigger mechanisms, trigger cascades.

Abstract

The possibilities of creating an intellectual bridge between the data of systemic biology and systemic medicine are explored. It is shown that creation of imitation models in silico are required to determine the role of trigger reactions, trigger cascades in the appearance of pathology. It is necessary to structure the accumulated medical knowledge, build ontological models of knowledge of different levels.

References

Solov'eva, O. E., Markhasin, B. C., Katsnel'son, L. B., Sul'man, T. B., Vasil'eva, A. D., & Kursanov, A. G. (2013). Matematicheskoe modelirovanie zhivykh sistem [Mathematical modeling of living systems]: a textbook. Ekaterinburg: The Ural University Publ.

Mintser, O. P., & Vatlitsov, D. V. (2016). Evolyutsiya uzagal'nennya, obroblennya ta peredavannya znan' u meditsini ta biologii [Evolution of generalization, processing and transfer of knowledge in medicine and biology]. Medichna informatika ta inzheneriya (Medical Informatics and Engineering), 1, 1-14. doi: http://dx.doi. org/10.11603/mie.1996-1960.2016.1.5904.

Mintser, O. P., & Vatlitsov, D. V. (2015). Ontologichna model' protsesiv programovanoi klitinnoi zagibeli [Ontological model of programmed cell death processes]. Medichna informatika ta inzheneriya (Medical Informatics and Engineering), 2, 14-26.

Mintser, O. P., & Babintseva, L. Yu. (2014). Pro zagal'ne vporyadkuvannya mediko-biologichnikh znan'. Stvorennya ontologii [On the general ordering of medical and biological knowledge. Creating an ontology]. Medichna informatika ta inzheneriya (Medical Informatics and Engineering), 2, 5-8.

Mintser, O. P., & Vatlitsov, D. V. (2015). Fotoaktivnist' biologichnikh molekul yak mozhlivii faktor koreguvannya triger zalezhnikh sistemnikh protsesiv (pershe povidomlennya) [Photoactivity of biological molecules as a possible factor for adjusting the trigger-dependent system processes (first message)]. Medichna informatika ta inzheneriya (Medical Informatics and Engineering), 4, 7-10.

Mintser, O. P., & Igrunova, K. M. (2014). Shchodo mezhi dotsil'nosti vikoristannya ponyattya «trigerni vzaemodii» u biologii ta meditsini. Pershe povidomlennya — postanovka problemi [On the limits of the expediency of using the concept of «trigger interactions» in biology and medicine. The first message — the statement of the problem]. Medichna informatika ta inzheneriya (Medical Informatics and Engineering), 4, 14-22.

Duncker, D. J., Bakkers, J., Brundel, B. J., Robbins, J, Tardiff, J. C., & Carrier, L. (2015). Animal and in silico models for the study of sarcomeric cardiomyopathies. Cardiovasc. Res., 105(4), 439-448. doi: 10.1093/cvr/ cvv006.

Vincent A., Nayar, P. G., Murugesan, R., Krishnan, J, & Ahmed, S. S. (2016). A systems biology and proteomics-based approach identifies SRC and VEGFA as biomarkers in risk factors mediated coronary heart disease. Mol. Biosyst., 12(8), 2594-2604. doi: 10.1039/ c6mb00264a.

Auffray, C., Chen, Z., & Hood, L. (2009). Systems medicine: the future of medical genomics and healthcare. Genome Med., 1(1), 2. doi:10.1186/gm1.

Bjornson, E., Boren, J., Mardinoglu, A. (2016). Personalized cardiovascular disease prediction and treatment — a review of existing strategies and novel systems medicine tools. Front. Physiol., 7, 2. doi: 10.3389/fphys.2016.00002.

Bressler, V. (2010). Medical humanism and professionalism teaching in a community hospital since World War II. In: The Pennsylvania Medical Humanities Consortium: Through the Lens of Time: Perspectives on Medicine and Health Care. Philadelphia (May 19-20, 2010).

The medical biochemistry page. (2017, December 17). Cholesterol. Retrieved from https:// themedicalbiochemistrypage.org/cholesterol.php.

Dorn, G. W., & Force, T. (2005). Protein kinase cascades in the regulation of cardiac hypertrophy. J. Clin. Invest., 115(3), 527-537. doi: 10.1172/JCI200524178.

Perrino, C, Barabasi, A. L., Condorell, G., Davidson, S. M., De Windt, L., Dimmeler, S., Engel, F. B., ... Ferdinandy, P. (2017). Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovasc. Res., 113(7), 725-736. doi: 10.1093/ cvr/cvx070.

Galland, L. (2006). Patient-centered care: antecedents, triggers, and mediators. Altern. Ther. Health Med., 12(4), 62-70.

Hoefer, I. E., den Adel, B, & Daemen, M. J. (2013). Biomechanical factors as triggers of vascular growth. Cardiovasc. Res., 99(2), 276-283. doi: org/10.1093/cvr/ cvt089.

Bielekova, B., Vodovotz, Y., An, G., & Hallenbeck, J. (2014). How implementation of systems biology into clinical trials accelerates understanding of diseases. Front. Neurol., 5, 102. doi: 10.3389/fneur.2014.00102.

Hoehndorf, R., Dumontier, M., Gennari, J. H., Wimalaratne, S., de Bono, B., Cook, D. L., & Gkoutos, G. V. (2011). Integrating system biology models and biomedical anthologies. BMC System Biology, 5, 124. doi: 10.1186/1752-0509-5-124.

Lehen'kyi, V., Shapovalov, G., Skryma, R., & Prevarskaya, N. (2011). Ion channels and transporters in cancer. 5. Ion channels in control of cancer and cell apoptosis. Am. J. Physiol. Cell Phisiol., 301(6), 1281-1289. doi: 10.1152/ajpcell.00249.2011.

Kahn, L. H., Kaplan, B., & Monath, T. P. (2009). 'One health' in action series: nos 1-8. Vet Ital., 45(1), 195-208.

Louridas, G. E., & Lourida, K. G. (2017). Conceptual foundations of systems biology explaining complex cardiac diseases. Healthcare, 5(1), E10. doi: 10.3390/ healthcare5010010.

MacLellan, W. R., Wang, Y., & Lusis, A. J. (2012). Systems-based approaches to cardiovascular disease. Nat. Rev. Cardiol., 9(3), 172-184. doi: 10.1038/ nrcardio.2011.208.

ast, F. D., Ratushny, A. V. & Aitchison, J. D. (2014). Systems cell biology. J. Cell. Biol., 206(6), 695-706. doi: 10.1083/jcb.201405027.

Muller, J. E., Tofler, G. H., & Stone, P. H. (1989). Circadian variation and triggers of onset of acute cardiovascular disease. Circulation, 79(4), 733-743. doi.org/10.1161/01.CIR.79.4.

Pain, T., Yang, X. M., Critz, S. D., Yue, Y., Nakano, A., Liu, G. S., Heusch, G., ... Downey, J. M. (2000). Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals. Circ. Res., 87(6), 460-466. doi: org/10.1161/01. RES.87.6.460.

Osler, W., & McCrae, T. (1920). The principles and practice of medicine: designed for the use of practitioners and students of medicine. 9th ed. N. Y., & London: Appleton & Company.

Fan, H., Sun, B., Gu, Q., Lafond-Walker, A., Cao, S., & Becker, L. C. (2002). Oxygen radicals trigger activation of NF-B and AP-1 and up regulation of ICAM-1 in reperfused canine heart. Am. J. Physiol. Heart Circ Physiol., 282, H1778-H1786. doi: 10.1152/ ajpheart.00796.2000.

Sperling, S. R. (2011). Systems biology approaches to heart development and congenital heart disease. Cardiovasc. Res., 91(2), 269-278. doi: 10.1093/cvr/ cvr126.

Kahn, L. H., Kaplan, B., Monath, T. P., & Steele, J. H. (2008). Teaching "one medicine, one health". Am. J. Med., 121(3), 169-170. doi: 10.1016/j. amjmed.2007.09.023.

Mesquita, E. T., Silva, E. N., Jorge, A. J., de Melo Mariano, B.; Cassino J. P.; Souza, C. V. Jr; ... Rocha, R. G. (2015). The paradigm of systems biology applied to cardiovascular diseases. Int. J. Cardiovasc. Sci., 28(1), 78-86. doi: org/10.5935/2359-4802.20150011.

Published

2018-06-05

How to Cite

Mintser, O. P., Babintseva, L. Y., & Kharchenko, N. V. (2018). ABOUT THE PARADIGM OF COMBINING SYSTEMIC BIOLOGY AND SYSTEMIC MEDICINE REPRESENTATIONS FOR FORMING A NEW LOOK AT DIAGNOSTICS AND TREATMENT OF ISCHEMIC HEART DISEASE. Medical Informatics and Engineering, (1), 5–12. https://doi.org/10.11603/mie.1996-1960.2018.1.8886

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