• T. A. Chernyshova Medical Center of National Aviation University
  • S. M. Zlepko Vinnytsia National Technical University
  • O. Yu. Azarkhov SHEI «Pryazovskyi State Technical University»
  • S. O. Danylkov Office of Health Care of the Mariupol City Council
  • V. Ye. Kryvonosov SHEI «Pryazovskyi State Technical University»
  • D. M. Baranovsky Vinnytsia National Technical University
Keywords: information technology, circulating tumor cells, oncology, diagnostic.


Most modern systems and technologies of the automated analysis of medical microscopic images and early diagnostics of oncological diseases are analyzed in the article. The methods and algorithms used for image processing, segmentation, determination of parameters of the object, which are determined manually and require additional knowledge, make it significantly complicated for their practical application in clinical medicine due to insufficient knowledge of medical staff.


Ablameiko, S. V., & Nedz'ved', A. M. (2005). Obrabotka opticheskikh izobrazhenii kletochnykh struktur v medit-sine [Processing of optical images of cellular structures in medicine]. Minsk: Joint Institute of Informatics Problems NAS of Belarus [in Russian].

Khankhashanova, T. D., Ryazantseva, N. V., Perinov, A. P., Medvedev, V. I., Chimitov, A. A., & Dambaev, G. T. (2011, March 3.) Ustroistvo dlya mikroproseivani-ya venoznoi krovi [Device for venous blood microseal-ing]. Pat. RU 2414710 S1, IPC G01N 33/49 (2006.01) C12M 3/06 (2006.01). No. 2009141746/15 [in Russian].

Starchenko, B. I., & Vishnevitskii, V. Yu. (2010). Bi-otekhnicheskie i meditsinskie tekhnologii [Biotechnical and medical technologies]: schoolbook. Taganrog: Engineering and Technology Academy of Southern Federal University Publ. [in Russian].

Cell Search. (2017, January 4). CELLTRACKS ANALYZER II® Laboratory Information System (LIS) Guide. Janssen Diagnostics. Retrieved from: https://

Van der Auwera, I., Peeters, D., Benoy, I. H., Elst, H. J., Van Laere, S. J., Prove, A., ... Dirix, L. Y. (2010). Circulating tumour cell detection: a direct comparison between the CellSearch System, the AdnaTest and CK-19/mammaglobin RT-PCR in patients with metastatic breast cancer. Br. J. Cancer, 102(2), 276-284.

Andreopoulou, E, Yang, L. Y., Rangel, K. M., Reuben, J. M., Hsu, L., Krishnamurthy, S., ... Cristofanilli, M. (2012). Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: Ad-naGen AdnaTest BreastCancer Select/Detect™ versus Veridex CellSearch™ system. Int. J. Cancer, 130(7), 1590-1597.

Deng, G., Herrler, M., Burgess, D., Manna, E., Krag, D., & Burke, J. F. (2008). Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients. Breast Cancer Res., 10(4), P. 69.

Nagrath, S, Sequist, L. V., Maheswaran, S., Bell, D. W., Irimia, D., Ulkus L., ... Toner, M. (2007). Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature, 450(7173), 1235-1239.

Bauer, K., de la Torre-Bueno, J., Diel, I. J., Hawes, D., Decker, W. J., Priddy, C., . Harrington, D. S. (2000). Reliable and sensitive analysis of occult bone marrow metastases using automated cellular imaging. Clin. Cancer Res., 6(9), 3552-3559.

How to Cite
Chernyshova, T. A., Zlepko, S. M., Azarkhov, O. Y., Danylkov, S. O., Kryvonosov, V. Y., & Baranovsky, D. M. (2018). INFORMATION TECHNOLOGIES AND SYSTEMS FOR EARLY DIAGNOSIS OF ONCOLOGY DISEASES BY THE LEVEL OF CIRCULATING TUMOR CELLS. Medical Informatics and Engineering, (4).