THE ROLE OF MACROPHAGES IN THE MORPHO- AND PATHOGENESIS OF NON-ALCOHOLIC STEATOHEPATITIS
DOI:
https://doi.org/10.11603/mie.1996-1960.2022.3.13367Keywords:
nonalcoholic steatohepatitis, liver fibrosis, macrophages, Kupffer cells, CD68, TREM-2, METAVIRAbstract
Background. The issues of modern data analytics are considered, among which the risk of discrimination is the most acute. There are still no major studies on this topic in pathomorphology. Our work aims to identify the causes and consequences of discrimination in data mining and explore potential solutions to this problem. The purpose of the work was to identify the correlation between the number of CD68-positive Kupffer cells in liver biopsies and the degree of liver fibrosis according to the METAVIR index.
Materials and methods. Results. According to the results of the study, it was established that there is a statistically significant difference between the expression levels of the CD68 marker between different groups of patients, divided by the degree of liver fibrosis according to the METAVIR index. It was proved that there is a statistically significant linear correlation between the expression levels of the CD68 marker and the degree of liver fibrosis according to the METAVIR Index.
Conclusions. In the future, it is necessary to investigate the hypothesis regarding the correlation between the number of a subpopulation of scar-associated liver macrophages (TREM2 and CD9 positive macrophages) and the degree of liver fibrosis, based on the statistically reliable results of this study.
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