THE ROLE OF MACROPHAGES IN THE MORPHO- AND PATHOGENESIS OF NON-ALCOHOLIC STEATOHEPATITIS
DOI:
https://doi.org/10.11603/mie.1996-1960.2022.3.13367Keywords:
nonalcoholic steatohepatitis, liver fibrosis, macrophages, Kupffer cells, CD68, TREM-2, METAVIRAbstract
Background. The issues of modern data analytics are considered, among which the risk of discrimination is the most acute. There are still no major studies on this topic in pathomorphology. Our work aims to identify the causes and consequences of discrimination in data mining and explore potential solutions to this problem. The purpose of the work was to identify the correlation between the number of CD68-positive Kupffer cells in liver biopsies and the degree of liver fibrosis according to the METAVIR index.
Materials and methods. Results. According to the results of the study, it was established that there is a statistically significant difference between the expression levels of the CD68 marker between different groups of patients, divided by the degree of liver fibrosis according to the METAVIR index. It was proved that there is a statistically significant linear correlation between the expression levels of the CD68 marker and the degree of liver fibrosis according to the METAVIR Index.
Conclusions. In the future, it is necessary to investigate the hypothesis regarding the correlation between the number of a subpopulation of scar-associated liver macrophages (TREM2 and CD9 positive macrophages) and the degree of liver fibrosis, based on the statistically reliable results of this study.
References
Marengo, A., Jouness, R. I. K., Bugianesi, E. (2016). Progression and Natural History of Nonalcoholic Fatty Liver Disease in Adults. Clin Liver Dis. 20(2), 313-324. DOI: 10.1016/j.cld.2015.10.010.
Matteoni, C. A., Younossi, Z. M., Gramlich, T., Boparai, N., Liu, Y. C., McCullough, A. J. (1999). Nonalcoholic Fatty Liver Disease: A Spectrum of Clinical and Pathological Severity. Gastroenterology. 116(6), 1413-1419. DOI: 10.1016/j.cld.2015.10.010.
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., Wymer, M. (2016). Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 64(1), 73-84. DOI: 10.1002/ hep.28431.
Sheka, A. C., Adeyi, O., Thompson, J., Hameed, B., Crawford, P. A., Ikramuddin S. (2020). Nonalcoholic steatohepatitis: a Review. JAMA. 23, 1175-1183. DOI: 10.1001/jama.2020.2298.
Kazankov, K., Jorgensen, S. M. D., Thomsen, K. L., Moller, H. J., Vilstrup, H., George, J., Schuppan, D., Gronbaek, H. (2019). The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Nat Rev Gastroenterol Hepatol. 16, 145-159. DOI: 10.1038/s41575-018-0082-x.
Hundertmark, J., Krenkel, O., Tacke, F. (2018). Adapted immune responses of myeloid-Derived cells in fatty liver disease. Front Immunol. 9, 2418. DOI: 10.3389/fimmu.2018.02418.
Schwabe, R. F., Tabas, I., Pajvani, U. B. (2020). Mechanisms of fibrosis development in nASH.
Gastroenterology. 158, 1913-1928. DOI: 10.1053/j. gastro.2019.11.311.
Tacke, F., Zimmermann, H. W. (2014). Macrophage heterogeneity in liver injury and fibrosis. 60, 10901096. DOI: 10.1016/j.jhep.2013.12.025.
Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T. et al. (2019). Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Nature. 575, 512-518. DOI: 10.1038/s41586-019-1631-3.
Lawitz, E. J., Shevell, D. E., Tirucherai, G. S., Du, S. et al. (2021). BMS-986263 in Patients with Advanced Hepatic Fibrosis: 36-Week Results from a Randomized, Placebo-Controlled Phase 2 Trial. Hepatology. 75(4), 912-923. DOI: 10.1002/hep.32181.
Yongming, W., Jia, M. (2019). Applying Statistical Methods to Library Data Analysis. The Serials Librarian. 76, 1-4, 195-200. DOI: 10.1080/0361526X.2019.1590774.
Hossain, Parash, M. T., Rahman, M. M., Naushaba, H., Sharmin, H., Choudhury, S. (2022). Simple linear regression approach for evaluating models to estimate stature based on upper limb dimensions of adult Bangladeshi males. Egypt J Forensic Sci. 12(20). DOI: 10.1186/s41935-022-00277-3.
Downloads
Published
How to Cite
Issue
Section
License
Journal Medical Informatics and Engineering allows the author(s) to hold the copyright without registration
The majority of Medical Informatics and Engineering Open Access journals publish open access articles under the terms of the Creative Commons Attribution (CC BY) License which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The remaining journals offer a choice of licenses.
This journal is available through Creative Commons (CC) License CC-BY 4.0
