• O. P. Mintser Shupyk National Medical Academy of Postgraduate Education
  • V. M. Zaliskyi Shupyk National Medical Academy of Postgraduate Education
  • L. Yu. Babintseva Shupyk National Medical Academy of Postgraduate Education
Keywords: self-organization, self-assembling, tissue engineering, tissue engineering platforms, bone, cardiovascular, liver and corneal tissues


Background. An analytical study examines the processes of self-organization and self-assembly as processes of frameless tissue engineering. The characteristics and advantages of each process are described, and key examples of fabrics created using these processes on the basis of frameless tissue-engineering platforms are considered in order to outline recommendations for future tissue engineering developments in the clinic.

Purpose. The purpose of this review is to integration of achievements in the field of frameless tissue engineering, primarily associated with self-organization and the process of self-assembly.

Results. Materials and methods. It is postulated that one of the most promising areas of research is the self-assembly process, which leads to the formation of functional tissue in a cellular way that does not require external energy input. At the same time, the justification and identification of the system of complex tissue formation optimal by a given criterion — free from a scaffold or based on a scaffold — is a non-trivial task of combining various systems and independent cell types.

Conclusion. One of the most promising areas of research is the self-assembly process, which leads to the formation of functional tissue in a cellular way that does not require external energy input. The justification and identification of a system of complex tissue formation optimal by a given criterion — free from a scaffold or based on a scaffold — is a non-trivial task of combining various systems and independent cell types.


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