TRANSFORMATION OF KNOWLEDGE OF ATHEROGENESIS: THE USE OF NANO-ASSOCIATED BIO-TECHNOLOGIES AND NETWORK ANALYSIS
DOI:
https://doi.org/10.11603/mie.1996-1960.2019.1.10106Keywords:
atherosclerosis, atherogenesis, nanoscale compounds, inflammation, signalling, liver receptor LXRs, modeling of atherogenesisAbstract
Background. The issues of changing knowledge of the occurrence, development and prevention of atherosclerosis are considered. It is shown that the concept of the role of inflammation as a CVD core is currently of paramount importance.
Materials and methods. Results. Postulated that microbes can influence atherogenesis in various direct or indirect ways and, therefore, they should be considered as factors contributing to the progression of atherosclerosis. Thus, the concept contributes to further research in this area. It is emphasized that the hepatic receptor LXRs lie at the intersection of lipid metabolism, innate immunity, inflammation and all the main pathways for the development of atherosclerotic lesions and CVD.
Conclusions. It seems important to focus on the processes of nano-mediated detection and therapeutic control of the development of atherosclerosis using cell targeting (intima macrophages, foam cells, endothelial cells) and processes (neo-hyogenesis, proteolysis, apoptosis, thrombosis, high-density lipoprotein metabolism). (HDL) and inflammation).
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