CLINICAL AND ANAMNESTIC FEATURES OF ARTERIAL HYPERTENSION IN YOUNG PEOPLE WITH DISHARMONIC LIPID COMPONENT OF BODY WEIGHT

Authors

  • І. І. Кyrychenko Kharkiv Medical Academy of Postgraduate Education Military Medical Clinical Center of the Northern Region of the Ministry of Defense of Ukraine
  • A. S. Shklyar Kharkiv National Medical University
  • N. V. Demikhova Sumy State University
  • H. А. Tereshchenko Sumy State University

DOI:

https://doi.org/10.11603/bmbr.2706-6290.2020.2.11380

Keywords:

arterial hypertension, overweight, young age, cardiovascular risk

Abstract

Summary. According to experts from the World Health Organization, cardiovascular disease is a major etiological factor in disability and mortality. Ukraine is the leader in mortality from cardiovascular disease among European countries. Overweight is the one of the proven and modified risk factors of hypertension. Particular attention is drawn to the growing incidence of arterial hypertension (AH) among young people of working age. Elevated blood pressure is the cause of nine million deaths each year. This risk can be significantly reduced by early diagnosis and appropriate prevention methods.

The aim of the study – to determine the clinical and anamnestic features that are important for assessing the level of cardiovascular risk (CVR) and to substantiate, on this basis, the algorithm for determining CVR in hypertension in obese young people.

Materials and Methods. According to the inclusion/exclusion criteria, 74 patients were included in the study in accordance with the Recommendations of the European Society of Cardiology for the treatment of hypertension 2018 and the Order of the Ministry of Health of Ukraine No. 384 of May 24, 2012. Physical and laboratory methods of examination, ultrasound and determination of the level of cardiovascular risk (CVR) of the respondents were divided into two groups. The study examined 74 patients aged 18–44 years with a verified diagnosis of hypertension and overweight of varying degrees, who were divided into two clinical groups, depending on the level of CVR (21 people with low CVR and 53 patients with moderate CVR).

Results. The problem of cardiovascular risk assessment among young people with hypertension of degree 1 with overweight and further demonstrated the informativeness of anamnestic, anthropometric data, some indicators of systemic inflammation and hormonal activity of adipose tissue, as well as indicators of vascular wall. For young people with hypertension of degree 1 and overweight, a tabular algorithm for assessing the level of CVR, which is based on the criteria specific to this category of patients, available for use at the primary level of care.

Conclusion. The use of the algorithm allows you to personalize the sequence of examinations to obtain a predictive assesment of the level of CVR, as well as the choice of tactics of patients.

References

Grinevich VB, Sas YeI, Kravchuk YuA. [Abdominal obesity: clinical and social aspects of the problem]. Ozhireniye i metabolizm.2012;2: 28-32. Russian. DOI: https://doi.org/10.14341/omet2012228-32

Dedov II, Melnichenko GA. Obesity. [Ожирение] Moscow: MIA; 2004. Russian.

Berrington de Gonzalez A. Body-mass index and mortality among 1,46 million white adults. New Eng Journal Med. 2010;363(23): 2211-19. DOI: https://doi.org/10.1056/NEJMoa1000367

Bogaert YE, Linas S. The role of obesity in the pathogenesis of hypertension. Nature Clinical Practice Nephrology. 2009;5(2): 101-11. DOI: https://doi.org/10.1038/ncpneph1022

Chernatska O, Demikhova N, Rudenko T, Demikhov A. Assesment of the lipid profile correction in patients with arterial hypertension and type 2 diabetes mellitus. Azerbaijan Medical Journal. 2019;1: 95-9.

Demikhov O, Dehtyarova I, Rud O. Arterial hypertension prevention as an actual medical and social problem. Bangladesh Journal of Medical Science. 2020;19(4): 722-9. DOI: https://doi.org/10.3329/bjms.v19i4.46632. DOI: https://doi.org/10.3329/bjms.v19i4.46632

European Guidelines on cardiovascular disease prevention in clinical practice. European Heart Journal. 2016;3(37): 2315-81.

Ferket BS, van Kempen BJ, Hunink MG. Predictive value of updating Framingham risk scores with novel risk markers in the U.S. General population. PLoS One. 2014;9(2): 883-912.

Published

2020-09-17

How to Cite

Кyrychenko І. І., Shklyar, A. S., Demikhova, N. V., & Tereshchenko H. А. (2020). CLINICAL AND ANAMNESTIC FEATURES OF ARTERIAL HYPERTENSION IN YOUNG PEOPLE WITH DISHARMONIC LIPID COMPONENT OF BODY WEIGHT. Bulletin of Medical and Biological Research, (2), 39–44. https://doi.org/10.11603/bmbr.2706-6290.2020.2.11380