COMPREHENSIVE APPROACH TO THE TREATMENT OF TUBO-PERITONEAL INFERTILITY IN WOMEN WITH COMBINED VULVOVAGINAL AND CERVICAL INFECTIONS
DOI:
https://doi.org/10.11603/24116-4944.2025.1.15407Keywords:
infertility, vulvovaginal infections, cervical infections, diagnosis, treatment optimization, reproductive function, ozone therapyAbstract
The aim of the study – to assess the impact of urogenital infections on female reproductive function and to develop an effective, individualized treatment algorithm incorporating ozone therapy as a promising adjuvant method.
Materials and Methods. The study involved 150 women of reproductive age diagnosed with infertility (both primary and secondary forms). All participants underwent comprehensive clinical, instrumental, microbiological, and immunological examinations. The main group consisted of 75 women who, in addition to standard treatment, received ozone therapy (vaginal instillations and ozone-oxygen infusions), while the control group of 75 patients received only conventional antibacterial and anti-inflammatory therapy.
Results and Discussion. Analysis of the results demonstrated that the inclusion of ozone therapy led to a significant improvement in clinical outcomes: the pregnancy rate within six months after treatment was 47 % in the main group versus 18 % in the control group, reflecting a 2.6-fold increase in treatment effectiveness (p<0.01). Furthermore, normalization of the vaginal microbiota, reduction in pro-inflammatory cytokine levels, and improvement in local immune parameters were observed.
Conclusions. These findings confirm the clinical value of incorporating ozone therapy into comprehensive treatment protocols for infection-related infertility as an effective and pathogenetically justified therapeutic component capable of significantly improving reproductive outcomes.
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