General characteristics of JNK activation pathways.

A. L. Zahayko; O. A. Krasilnikova; A. B. Kravchenko

doi:10.11603/mcch.2410-681X.2016.v0.i4.7289

Автор(и)

A. L. Zahayko
O. A. Krasilnikova
A. B. Kravchenko

DOI:

https://doi.org/10.11603/mcch.2410-681X.2016.v0.i4.7289

Ключові слова:

c-jun N-термінальні протеїнкінази, мітогенактивовані протеїнкінази, активні форми кисню, стрес ендоплазматичного ретикулума, жирні кислоти, метилгліоксаль, сфінголіпіди.

Анотація

c-Jun N-термінальні протеїнкінази (JNK) – представники сімейства мітогенактивованих протеїнкіназ (МАР-кіназ) – активуються у відповідь на дію різноманітних факторів, серед яких виділяють оксидативний, тепловий, осмотичний стрес, дію на клітини цитокінів та факторів росту і багато інших. Їх активація залучена в патогенез інсулінорезистентності, цукрового діабету та супутніх патологій, що визначає вибір JNK як терапевтичної мішені при створенні нових препаратів.

Метою даної роботи було проаналізувати й узагальнити інформацію про шляхи активації JNK, а також про основні клітинні метаболіти, які беруть участь у цьому процесі.

На даний час встановлено існування основних шляхів активації JNK, серед яких запуск МАР-кіназного каскаду, опосередкований взаємодією лігандів з рецепторами на плазматичній мембрані, утворення активних форм кисню, а також стрес ендоплазматичного ретикулума. Серед клітинних метаболітів до активації JNK залучені метилгліоксаль, лізо- і сфінголіпіди, жирні кислоти.

У клітині одночасно існує кілька головних механізмів активації ферменту. Деякі метаболіти, зокрема вільні жирні кислоти і лізоліпіди, мають також свій шлях активації ферменту. В активації JNK спостерігається тканинна специфічність, що важливо враховувати при розробці нових інгібіторів JNK.

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