THE EFFECT OF HEAVY METALS SALTS AND GLYPHOSATE ON THE LIPID METABOLISM

Abstract

Introduction. Lead is a protoplasmic poison harmful to varieties of organs and tissues as all heavy metals. Get into the body it violates enzymatic reactions, depresses the immunobiological resistance of the organism, syntheses of proteins, lipids, carbohydrates, and their metabolism. Lipid and lipoprotein abnormalities play a key role in the most pathogenesis process: progression of cardiovascular diseases, liver diseases, kidney diseases and other.

The aim of the study – to research the effect of the combined action of heavy metals salts (Plumbum and Cuprum) and organophosphorus roundup pesticide on indices of lipid metabolism in blood plasma of rats.

Research Methods. Experiments were performed on mature lab nonlinear white male rats with body weight of 150–200 g., which were injected intragastrically for 30 days with the lead acetate, the copper sulfate, the glyphosate (in herbicide Roundup). The disorders of lipid metabolism indices were detected by the changes in blood serum the following were estimated: total lipid, triglycerides, total cholesterol, high-density and low density lipoproteins.

Results and Discussion. It has been established that when administered to rats of aqueous solutions, Plumbum acetate, Kuprum sulfate and roundup in combination and separately led to a decrease in blood plasma of affected animals with high density lipoproteins, triglycerides, increased total lipids, total cholesterol and low density lipoprotein.

Conclusions. Introduction to rats Plumbum acetate, Kuprum sulfate and roundup resulted in a violation of lipid metabolism in animal blood.