FEATURES OF THE STATE OF PROOXIDANT SYSTEM WITH EXPERIMENTAL PERITONITIS AGAINST THE BACKGROUND OF DIABETES

Abstract

Summary. Acute peritonitis increasingly leads to the development of severe postoperative complications, the percentage of fatal cases increases. Diabetes mellitus continues to be one of the urgent problems of medicine, because it is one of the most common endocrine diseases with a persistent tendency to grow.

The aim of the study – to learn the features of prooxidant status in the body of experimental animals with simulated acute peritonitis on the background of diabetes mellitus compared with animals with experimental acute peritonitis.

Research Methods. In the work we used 56 white rats. Diabetes mellitus was modeled by intraperitoneal administration of streptozotocin from Sigmal (7 mg per 100 g of animal’s body), acute disseminated peritonitis – administration of 0.5 ml of 10 % filtered fecal suspension into the abdominal cavity of the studied animals. Determined indicators of prooxidant status in serum at 1, 3 and 7 days from the beginning of the simulated peritonitis.

Results and Discussion. It was proved that in animals with acute peritonitis on the background of diabetes mellitus, free radical oxidation processes are significantly activated, which is confirmed by statistically significantly higher levels of TBA-active products, hydroperosids, oxidative modification of proteins compared to the group of animals with simulated acute peritonitis. The detected intensification of oxidation processes indicates a significant activation of the organism's aggression factors in acute peritonitis against the background of diabetes mellitus.

Conclusions. In animals with acute common peritonitis, free radical oxidation processes are significantly activating against the background of diabetes, which is confirmed by statistically significantly higher levels of TBA-active products, lipid hydro peroxides, and an oxidative modification of neutral and basic proteins compared to a group of animals with a pattern of acute common peritonitis. The revealed intensification of oxidation processes indicates a significant activation of the aggression of the organism in acute common peritonitis on the background of diabetes mellitus.