PECULIARITIES OF THERAPEUTIC AND PROPHYLACTIC MEASURES IN CHILDREN OF EARLY AGE WITH PHOSPHORUS AND CALCIUM METABOLISM DISORDERS

Abstract

Introduction. Vitamin D is a substrate essential for the human body that plays a key role in the metabolism of calcium and phosphorus and accordingly is important for the development of a child.

The aim of the study – to research the peculiarities of phosphorous and calcium homeostasis and to supply the children of early age born with a high body mass with vitamin D.

Materials and Methods. The study included 82 children aged 3 to 6 months, with birth weight over 2.500 g and gestational age 37 weeks or more.

When a disruption of phosphorous and calcium homeostasis and the lack of 25–OH vitamin D3 was detected, in order to eliminate the main symptoms of a disease of the bone, nervous and other systems and normalization of phosphorous and calcium metabolism indicators, a correction was made with vitamin D₃ preparations according to protocol No. 9 of the Ministry of Health of Ukraine dated January 10. 2005.

Results and Discussion. In order to evaluate the availability of 25(OH)D3 in children with vitamin D deficiency rickets, a 25(OH)D serum concentration was determined as a biochemical marker of bone remodeling.

Between the indicators of calcium (serum) and the level of 25-OH vitamin D3 after treatment there is a reliable, direct, moderate correlation (R = 0.560; p = 0.0126) in boys only. Between the indicators of alkaline phosphatase (blood serum) and the level of 25-OH vitamin D3 after treatment, there is a reliable, reverse, strong relationship (R = -0.555; p<0.001). That is, with a higher level of alkaline phosphatase after treatment, there is a tendency towards a decrease in the level of 25-OH vitamin D3.

Conclusions: 1. Children born with a high body mass over 4.000 g have vitamin D3 deficiency compared to children born with normal body mass.

2. Weight at birth and at the time of examination correlate with the level of vitamin D3 and is a risk factor of vitamin D3 deficiency (negative correlation).

3. Correction of vitamin D3 deficiency results in positive dynamics.