FEATURES OF PRO- AND ANTIOXIDANT SYSTEM AND METABOLISM OF FIBROUS TISSUE IN PATIENTS WITH POSTOPERATIVE VENTRAL HERNIA ON THE BACKGROUND OF COMORBIDITY

Abstract

Introduction. The problem of recurrence of postoperative ventral hernias (POVH) continues to be one of the most urgent. The use of mesh implants in the treatment of POVH significantly reduced the number of complications and relapses, but their frequency remains high.

The aim of the study – to learn the features of pro- and antioxidant status and the exchange of connective tissue in patients with POVH under comorbid conditions, depending on the type of mesh implant.

Research Methods. 276 patients with POVH (main and comparative groups) were examined, who were separated by type of implanted polypropylene mesh during surgical intervention in order to assess the state of connective tissue metabolism.

Results and Discussion. It has been proved that the use of a lightweight mesh Omega-2 in combination with a PRF membrane in the surgical treatment of patients with POVH in conditions of comorbidity better contributes to the improvement of indicators of the exchange of connective tissue and prooxidant-antioxidant status compared to the use of light and heavy mesh.