APPLICATION OF EXTRACT FROM HOSTA LONCETOLISTIC FOR CORRECTION OF METABOLIC DISORDERS IN CONDITIONS OF ADRENALINE DISORDER OF MYOCARDIUM

Abstract

Introduction. One of the features of the development of heart diseases is the activation of lipid peroxidation processes, an increase in the number of prooxidant processes, which is a consequence of the effects on the living system of hemodynamic disorders and the hypoxic phenomena caused by them. For the treatment of diseases of the cardiovascular system, plant preparations are used on the basis of substances of flavonoid nature, which differ in a wide range of activities. The use of drugs based on these substances is due to pronounced antiradical properties.

The aim of the study– to establish antioxidant and membrane protective properties of the dry extract from the leaves of the lanceolithic hosts on the model of myocardial damage by toxic doses of adrenaline.

Research Methods. The studies were performed on white male rats, who were simulated necrotic myocardial damage by administering 0.18% adrenaline hydrotartrate solution at a rate of 0.5 mg/kg body weight.One of the groups of animals affected by adrenaline was taken by the extract from the leaves of the hosts at a dose of 100 mg/kg of body weight, the other – a cardioprotective corvitin at a dose of 42 mg/kg of body weight.In the blood serum, the content of TBA-active products, activity of aspartateaminotransferase and creatinephosphokinase, superoxide dismutase activity and ceruloplasmin content, in the myocardium–the content of TBA-active products and the above-mentioned organ-specific enzymes were determined.

Results and Discussion. It was found that the administration of epinephrine at a dose of 0.5 mg/kg of body weight led to the activation of LPO processes in the myocardium and serum of rats, as indicated by an increase in the content of TBA-active products within 48 hours from the start of the experiment.At the same time, there was a decrease in serum of superoxidedismutase activity and an increase in the content of ceruloplasmin, which indicates a profound disturbance in the enzyme link of the antioxidant system. The study of the activity of aspartateaminotransferase in the serum of rats affected by adrenaline showed its increase in all terms of the study and a decrease in the myocardium.Similar changes were noted in the study of the activity of creatinephosphokinase in animals after the development of adrenaline cardiopathy. The use of leaf extract from lanceolitic hosts showed an effective effect on pro and antioxidant indices in rats after injury, and also led to a normalization of the activity of organospecific myocardial enzymes.

Conclusion. Dry leaf extract from lanceolitic hosts showed antioxidant properties under conditions of adrenaline cardiopathy, which may be a prerequisite for further experimental studies of this drug.