Problem of assessment of pesticides neurotoxicity for the development of organism
DOI:
https://doi.org/10.11603/mcch.2410-681X.2018.v0.i2.9145Keywords:
рesticides, nervous system, neurological disorders, prenatal period, postnatal period, guideline 426.Abstract
Introduction. The results of many independent studies indicate a potential hazard to human health after exposure to chemical agents, in particular pesticides. Pesticides are chemical compounds that are widely used in agriculture, forestry, industry and everyday life for the control of pests. Pesticides are one of the environmental pollutants. Despite of the precautionary sanitary and hygienic measures in use, there is an increase in the presence of pesticides in atmospheric air, indoor and outdoor air, also in the processing of agricultural land in the soil and reservoirs; there is a presence of residual amounts in food. All these factors contribute to the enter of these compounds in the human body, which in future may be one of the causes of various diseases of chemical etiology. The nervous system during of ontogeny is one of the most vulnerable to the influence of chemicals. According to epidemiological evidence suggests that exposure to chemicals, including pesticides on the body in the pre- and postnatal period may lead to such neurological disorders in children as autism spectrum disorders, attention deficit hyperactivity disorder, learning disabilities and emotional and behavioural problems. Epidemiological observations indicate the association of these compounds with the development of the nervous system in children, but it is difficult to identify. The main source of information on possible negative effects of pesticides is the results obtained in experiments on laboratory animals. OECD guideline 426 focuses on the study of the functional development of the nervous system under the influence of pesticides in the pre and postnatal period.
The aim of the study – to learn modern sources of literature on the study of the relationship between the action of pesticides on the body of pregnant women and the development of the fetus.
Conclusion. Determination of the potential danger of pesticides for the developing organism is a priority. Scientific publications on epidemiological data indicate the relationship of exposure of pesticides in the pre- and postnatal period to the emergence of neurological disorders in descendants.
References
Adams, D. (2017). Insecticides and pesticides: Techniques for crop Protection.
Maksymiv, I.V. (2015). Pesticides: benefits and hazards. Journal of Vasyl Stefanyk Precarpathian National University, 2 (1), 71-77.
Kim, K.H., Kabir, E., & Jahan, S.A. (2017). Exposure to pesticides and the associated human health effects. Science of the Total Environment, 575, 525-535.
Mostafalou, S., & Abdollahi, M. (2013). Pesticides and human chronic diseases: evidences, mechanisms, and perspectives. Toxicology and Applied Pharmacology,268 (2), 157-177.
Liu, J., & Schelar, E. (2012). Pesticide exposure and child eurodevelopment: summary and implications. Workplace Health & Safety, 60 (5), 235-242.
Stryzhova, N.V., & Mashayeva, L.L. (1996). Vlyianye ksenobiotikov na beremennost [Influence of xenobiotics on pregnancy]. Akush. i ginekolog. – Obstetrics and Gynecology, 3, 20-23 [in Russian].
Wang, L., Wu, T., Liu, X., Anderson, J. L., Alamian, A., Fu, M., & Li, J. (2012). Pesticide exposure during pregnancy and low birth weight. WHO South-East Asia Journal of Public Health, 1 (3), 232.
Mayhoub, F., Berton, T., Bach, V., Tack, K., Deguines, C., Floch-Barneaud, A., ... & Chardon, K. (2014). Self-reported parental exposure to pesticide
during pregnancy and birth outcomes: The MecoExpo cohort study. PloS One, 9 (6), e99090.
Rappazzo, K.M., Warren, J.L., Meyer, R.E., Herring, A.H., Sanders, A.P., Brownstein, N.C., & Luben, T.J. (2016). Maternal residential exposure to
agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort. Birth Defects Research Part A: Clinical and Molecular Teratology, 106 (4), 240-249.
Garry, V.F. (2004). Pesticides and children. Toxicology and Applied Pharmacology, 198, 152-163.
Bjørling-Poulsen, M., Andersen, H. R., & Grandjean, P. (2008). Potential developmental neurotoxicity of pesticides used in Europe. Environmental Health, 7 (1), 50.
Rauh, V.A., Perera, F.P., Horton, M.K., Whyatt, R.M., Bansal, R., Hao, X., ... & Peterson, B.S. (2012). Brain anomalies in children exposed prenatally
to a common organophosphate pesticide. Proceedings of the National Academy of Sciences, 109 (20), 7871- 7876.
Rice, D., & Barone Jr.S. (2000). Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environmental Health Perspectives, 108 (3), 511.
Kyrylova, L.H., & Lysytsia, V.V. (2010). Vrodzheni vady rozvytku tsentralnoi nervovoi systemy – nahalna medyko-sotsialna problema derzhavnoho znachennia [Congenital malformations of the development of the
central nervous system are a common medical and social problem of state importance]. Ukrainskyi medychnyi chasopys – Ukrainian Medical Journal, 6 (80), 35-38 [in Ukrainian].
Posar, A., & Visconti, P. (2017). Autism in 2016: the need for answers. Jornal de Pediatria, 93 (2), 111-119. 16. Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., & Charman, T. (2006). Prevalence
of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). The Lancet, 368
(9531), 210-215.
Brugha, T.S., McManus, S., Bankart, J., Scott, F., Purdon, S., Smith, J., & Meltzer, H. (2011). Epidemiology of autism spectrum disorders in adults in the community in England. Archives of General Psychiatry, 68 (5), 459-465.
Abrahams, B.S., & Geschwind, D.H. (2008). Advances in autism genetics: on the threshold of a new neurobiology. Nature Reviews Genetics, 9 (5), 341.
Waye, M.M., & Cheng, H.Y. (2018). Genetics and epigenetics of autism: A Review. Psychiatry and Clinical Neurosciences, 72 (4), 228-244.
Freitag, C.M. (2007). The genetics of autistic disorders and its clinical relevance: a review of the literature. Molecular Psychiatry, 12 (1), 2.
Goin-Kochel, R. P., Trinh, S., Barber, S., & Bernier, R. (2017). Gene disrupting mutations associated with regression in autism spectrum disorder. Journal of Autism and Developmental Disorders, 47 (11), 3600-3607.
Xu, G., Strathearn, L., Liu, B., & Bao, W. (2018). Prevalence of Autism Spectrum Disorder Among US Children and Adolescents, 2014-2016. Jama, 319 (1), 81-82.
AlSagob, M., Colak, D., & Kaya, N. (2015). Genetics of autism spectrum disorder: an update on copy number variations leading to autism in the next generation sequencing era. Discovery Medicine, 19 (106), 367-379.
Nakaz Ministerstva okhorony zdorovia Ukrainy vid 15.06.2015 № 341. (2015). Rozlady autystychnoho spectra (Rozlady zahalnoho rozvytku) [Order of the Ministry of Health of Ukraine dated June 15, 2015, No. 341. Disadvantages of the optical spectra (discharge of general development]. [in Ukrainian].
Organisation for Economic Co-operation and Development. (2007). Test No. 426: Developmental Neurotoxicity Study. OECD Publishing.
