The problem of assessment of reproductive toxicity (gonadotoxic) pesticides
DOI:
https://doi.org/10.11603/mcch.2410-681X.2018.v0.i2.9136Keywords:
reproductive system, reproductive toxicity, pesticide, reproductive health.Abstract
Introduction. The deterioration of women's reproductive health, which is manifested in increased morbidity among pregnant women, reducing the number of normal births and to increase the variance of fetal development is of particular concern. It is known, that female reproductive system is especially sensitive to influence of negative factors of any origin.
The aim of the study – to investigate the problems of assessment of reproductive toxicity of pesticides.
Research Methods. We used general scientific research methods. They include analysis and synthesis, induction and deduction, analogy, abstraction and specification, system analysis, formalization.
Results and Discussion. Among the diseases that negatively affect reproductive health as a factor increasing the risk of ectopic pregnancy, infertility, disorders of menstruation, the appearance of tumors, significant importance are the inflammatory diseases of female genital organs. The incidence of this pathology remains high and is about 130.0/10 thousand women. Fundamental research of recent decades has allowed determining the basic mechanisms of the functioning of the reproductive system in women. Traced the relationship between ovarian function and the secretion of gonadotropins, mechanisms of regulation folliculogenesis in the ovaries, we formed a theory about the influence of sex hormones on the tonic and cyclic secretion of gonadotropins by the pituitary gland, proven the rhythm of their secretion. This allowed us to determine not only the main regularities of the functioning of the reproductive system in norm, but also to establish the types of its disorders in various pathological conditions. pathological processes of the internal genital organs lead, to impairment of reproductive function in women which list each year is gradually updated and refined, which greatly contributes to the development of new and improvement of existing methods of instrumental and laboratory diagnosis. The notion of reproductive toxicity of chemical substances in the context of the identification of their risk to the reproductive system involves the ability of tested compounds to induce breach of its reproductive function in adult animals, and abnormal development in the offspring. However, it should be noted that for a number of reasons for the study of pathogenetic disorders in the process of embryogenesis is taken out of the context of all other studies to assess reproductive toxicity and methodologically radically different from them.
Conclusions. Our analysis of experimental and analytical data on reproductive toxicity showed the following: 1) 67 % of the pesticides belong to substances that can cause adverse effects on the function of reproduction; 2) among all the pesticides that have been subjected to study in the test system several generations of animals, and about 9% have selective toxic effect on the reproduction function; 3) a selective effect of pesticides on the reproduction function does not depend on the toxicity of drugs. The likelihood of identifying compounds with selective reproductive toxicity is approximately the same level for preparations 1-3 hazard class acute systemic toxicity. Based on the obtained results, we can speak about the importance of studying the characteristics of toxic action of pesticides on the reproductive system and search of new approaches in the assessment of reproductive toxicity (gonadotoxiс) pesticides
References
(2015). Zdorovye i okruzhauyushchaya sreda: reshenie problemi vozdeystviya zagryazneniya vozdukha na zdorovye [Health and the environment: addressing the impact of air pollution on health]. VOZ. A68/A/CONF./2 Rev.1 [in Russian].
Wigle D.T. (2008). Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J. Toxicol. Environ. Health B. Crit. Rev., 11 (5-6), 373-417.
Tatarchuk, T.F., & Sokolskiy, Ya.P. (2006). Endokrinnaya ginekologiya (klinicheskie ocherki). Chast І [Endocrine gynecology (clinical essays). Part I]. Kyiv: Zapovіt [in Russian].
Aylamazyan, E.K. (2005). Problema okhrany reproduktivnogo zdorovya zhenschiny v usloviyakh ekologicheskogo krizisa [Problem of protection of the
reproductive female health in in condition of ecological crisis]. Med. akad. zhur. – Medical Academical Journal, 2, 47-58 [in Russian].
Iskandarov, T.I. (2014). Kompleksnoe normirovanie pestitsidov v obyektakh okruzhayushchey sredy i ikh gigiyenicheskie normativy [Complex regulation of pesticides in environmental objects and their hygienic
standards]. Tashkent [in Russian].
Metodologiya kompleksnogo i uskorennogo normirovaniya pestitsidov v obyektakh okruzhayushchey sredy [Methodology of complex and accelerated standardization of pesticides in environmental objects]. Tashkent [in
Russian].
Lepeshko, P.N. (2017). Toksikologo-gigiyenicheskaya otsenka novykh khimicheskikh veshchestv vnedryaemykh v proizvodstvo [Toxicological and hygienic assessment of new chemicals introduced in production].
Minsk: BGMU [in Russian].
Kuligina, М.В. (2008). Reproduktivnoe povedenie i zdorovye naseleniya (mediko-sotsialnie aspekty) [Reproductive behavior and public health (medico-social aspects]. Ivanovo [in Russian].
Moiseienko, R.О. (2012). Reproduktyvne zdorovia naselennia Ukrainy yak osnovnyi kryterii efektyvnosti sotsialno-ekonomichnoi polityky derzhavy [Reproductive health of the population of Ukraine as the main criterion
for the effectiveness of the socio-economic policy of the state]. Ukraina. Zdorovia natsii – Ukraine. Health of the Nation, 2-3 (22-23), 86-91 [in Ukrainian].
(2005). Vzaiemozviazok dytiachoi somatychnoi
zakhvoriuvanostі v anamnezі zhіnok fertylnoho vіku zі stanom ikh reproduktyvnoho zdorovia (prohnozuvannia porushen) [Relationship of children’s somatic morbidity in anamnesis of women of fertile age with a state of their reproductive health]. Zdorovye zhenshchiny – Health of a Woman, 2 (22), 169-173 [in Ukrainian].
Kliuzko, V.M. (2010). Istorychni aspekty realizatsii pryntsypiv derzhavnoho upravlinnia v haluzi okhorony zdorovia [Historical aspects of implementation of state management principles in health care field].
Derzhava ta rehiony – State and Regions, 3, 213-217 [in Ukrainian].
Ahman, E., & Shah, I.H. (2011). [New estimates and trends regarding unsafe abortion mortality]. International Journal of Gynecology and Obstetrics, 115, 121-126.
Hoida, N.H. (2012). Normatyvno-pravove rehuliuvannia diialnosti sluzhby planuvannia simi ta zberezhennia reproduktyvnoho zdorovia [Normative-legal
regulation of the service Family Planning and Reproductive Health]. Chasopys – Herald, 4 (90), VII/VIIІ, 7-9 [in Ukranian].
Stankevich, V.V. (2005). Sovremennye aspekty narusheniya menstrualnogo tsykla u devochek-podrostkov [Modern aspects of disorders of menstrual cycle in girls teenagers]. Pedіatrіya, akusherstvo i gіnekologіya –
Pediatrics Obstetrics and Gynecology, 6, 68-71 [in Russian].
Radzinskiy, V.E. (Ed.). (2007). Zhenskaya consultatsiya [Women's consultation]. Petrozavodsk: Intel-tek [in Russian].
Osteen, K.D. (2013). Ekonomicheskie i politicheskie voprosy tendentsiy ispolzovaniya selskokhozyastvennogo pestitsida v SShA [Economic and policy
issues of U.S. agricultural pesticide use trends]. Pest Manag. Sci., 69, 1001–1025.
Yao, K.V. (2008). Progress v izuchenii muzhskoy reproduktivnoy toksichnosti piretroidnykh insektitsidov [Progress in studies of themale reproductive toxicity of pyrethroid insecticides]. Zhonghua Nan Ke Xue., 14 (3), 268-271.
Pro zatverdzhennia Derzhavnoi prohramy “Reproduktyvne zdorovia natsii” na period do 2015: postanova КМU vid 27.12.2006 р. № 1849 – http: //www.rada. gov.ua [in Ukranian].
Andersen, G.R. (2008) Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy. Environ. Health Perspect., 116, 566-572.
Damgaard, I.N., Skakkebaek, N.E., & Toppari, J. (2006). Persistent pesticides in human breast milk and cryptorchidism. Environ. Health Perspect., 114, 1133- 1138.
Rastogi, S.K., Tripathi, S., & Ravishanker, D. (2010). A study of neurologic symptoms on exposure to organophosphate pesticides in the children of agricultural workers. Indian J. Occup. Environ. Med., 14, 54-57.
Shepelskaya, N.R. (2013). Pishchevye kontaminanty: metodologicheskie podkhody k izucheniyu ikh reproduktivnoy toksichnosti [Food contaminants: methodological approaches to the study of their reproductive toxicity]. Problemy kharchuvannia – Problems of Nutrition, 1, 59-64 [in Russian].
