Correlation analysis of hemostasis indicators and functional liver conditions for acute calculosis cholecystite
DOI:
https://doi.org/10.11603/mcch.2410-681X.2017.v0.i4.8391Keywords:
correlation analysis, acute calculous cholecystitis, obstructive jaundice, hepatocytes, hemostasis system.Abstract
Introduction.Acute calculous cholecystitis (ACC) is characterized by the development of certain symptoms – from the local inflammatory process to significant functional disorders in the liver. The activity of the hemostasis system is directly related to the functional state of the liver, since hepatocytes are the main site for the synthesis of most proteins, in particular the proteins of the blood coagulation system.
The aim of the study – to establish the relationship between the hemostasis system and the functional state of hepatocytes in patients with acute calculous cholecystitis (ACC), uncomplicated and complicated by obstructive jaundice (OJ) using a correlation analysis.
Research methods.The subject of the study was plasma and serum of 47 patients with uncomplicated АСС (group I) and 32 patients with АСС with OJ (group II). For comparison, serum and blood plasma of 25 virtually healthy individuals, who were the control group, were examined. The parameters of the hemostasis system platelet count (prothrombin time (PT), activated partial thromboplastin time (APTT), total fibrinogen concentration (TFC), soluble fibrin-monomer complexes (SFMC), antithrombin III (ATIII) and Hageman-dependent fibrinolysis activity were determined (HDF). The determination of indicators of the liver function of the catalytic activity of alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) and cholinesterase (CHE) and the concentration of α1-antitrypsin (α1-AT),α2-macroglobulin (α2-MG) and C-reactive protein (CRP) was also made.
Results and Discussion. The revealed correlations allow determining the degree of conjugacy of processes. The less the number of bonds is the weaker conjugacy of processes, the more flexible becomes the system that responds to the pathological change of the internal environment. The greatest number of correlation bonds was established in the control group of patients. In patients with ACC without complications, there was a tendency to decrease the number of bonds, where α1-AT correlated most withthe investigated parameters. The reduction of the amount and the change of the structure of correlation bonds were found in patients with ACC with OJ. A new correlation between the studied parameters in this group of patients has also been established.
Conclusions.The established correlation bonds in uncomplicated ACC and complicated OJ indicate the tension of the adaptive mechanisms of the hemostasis system and the functional state of the liver when the inflammatory process complicates.
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