Experimental evaluation of melatonin, citicoline, corvitin and thiotriazoline effect on microcirculation in the vessels of the ciliary body of rabbits under contusion of the eye according to laser doppler flowmetry
DOI:
https://doi.org/10.11603/mcch.2410-681X.2017.v0.i2.7974Keywords:
melatonin, reference-drugs, contusion of an eye, eye perfusion, neuroretinoprotection, Laser Doppler Flowmetry.Abstract
Introduction. Neuroretinoprotective activity of melatonin is the basis for further comprehensive assessment of possible mechanisms of its protective action in order to reasonable implementation of the drug in ophthalmic practice as a remedy with neuroretinoprotective action for the treatment of traumatic lesions of eye.
The aim of the study – to learn Laser Doppler Flowmetry method to investigate the effect of melatonin and reference drugs (citicoline, corvitin and thiotriazoline) on completeness of recovery of blood flow in the vessels of the ciliary body in dynamic of its contusion as a possible mechanism of their neuroretinoprotective action.
Research Methods. Model of eye contusion is a blank shot into the center of the cornea closely with carbon dioxide under pressure. Therapy is separate intravenous administration of drugs (melatonin 10 mg / kg, corvitin 10 mg / kg citicoline 250 mg / kg and thiotriazoline 100 mg / kg) twice a day during 7 days, the first application 1 h after injury. Effect of drugs on microcirculation in the eye ciliary body in this condition was studied with using Laser Doppler Flowmetry module BIOPAC (USA).
Results and Discussion. Therapeutic application of all test substances amortized rapid deterioration of blood supply to the eye. Melatonin is the leader among the selected drugs for the ability to improve the circulation in the ciliary body of eye during the first week after its contusion.
Conclusion. Restoration of eye perfusion caused by contusion on the background of application of melatonin, citicoline, corvitin and thiotriazoline is one of the leading mechanisms of neuroretinoprotective action of these drugs.
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