The role of hypoxia and proton mechanism of parietal cells in the occurence of stress-induced and peptic ulcers
DOI:
https://doi.org/10.11603/mcch.2410-681X.2016.v0.i4.7285Keywords:
stress-induced ulcers, peptic ulcers, hypoxia.Abstract
Based on experimental and clinical research, the authors revealed the preventive and therapeutic effect of continued intragastric delivery of molecular oxygen in case of stress-induced and peptic erosions and ulcers of stomach and duodenum. The hypothesis of possible role of hypoxia in the mechanism of injury of parietal cells is based on a consequence of transfer of protons from matrix of mitochondria and its further accumulation in cytoplasm. In this situation, the H+-dependent processes occur, particularly ATP synthesis and production of hydrochloric acid for which the protons are used.
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