Roleofgasotransmitters: nitrogen oxide and hydrogen sulfide in smool intestine of rats under cyclooxygenase and lipoxygenase inhibition

Authors

  • Yu. O. Sklyarova
  • N. V. Denysenko
  • I. I. Ilkiv
  • I. S. Fomenko

DOI:

https://doi.org/10.11603/mcch.2410-681X.2016.v0.i3.6945

Keywords:

Cyclooxygenase, lipoxygenase, nitrogenoxide, hydrogensulfide, mucosa of small intestine.

Abstract

Inexperimentstherewerecomparedthecyclooxygenaseinhibitionbyindomethacinanddualcycloocygenaseandlipoxygenaseblockageby 4-thiazolidinonederivatives, capabletoreleasehydrogensulfidein small intestine. Itwasshownthatindomethacinwasaccompaniedbytheformationoflesions in the distal part ofsmall intestine, significantactivationofinducibleNO-synthase, thedecreaseofH2Sproduction, riseinmalonicdialdehydeconcentrationand activity of myeloperoxidase. Theadministrationof5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-4-thyoxo-thiazolidine-2-onand 2-[(4-chlor-phenyl-carbamoyl)-methyl]-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-acrylicaciddidn’tdemonstrateanulcerogenicactioninsmallintestine, thatwasprobablycausedbythereleaseofH2S from these compounds.

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Published

2016-11-21

How to Cite

Sklyarova, Y. O., Denysenko, N. V., Ilkiv, I. I., & Fomenko, I. S. (2016). Roleofgasotransmitters: nitrogen oxide and hydrogen sulfide in smool intestine of rats under cyclooxygenase and lipoxygenase inhibition. Medical and Clinical Chemistry, (3), 54–58. https://doi.org/10.11603/mcch.2410-681X.2016.v0.i3.6945

Issue

Section

ORIGINAL INVESTIGATIONS