The state of antioxidant system and bile formation function in the organism of rats affected by hexavalent chromium compounds
DOI:
https://doi.org/10.11603/mcch.2410-681X.2016.v0.i1.6280Abstract
The affection of different age rats by potassium dichromate (3 mg/kg) was led to the violation of antioxidant system. It was confirmed by decrease of the catalase rate and reduced glutathione content in blood serum and liver of experimental animals. The most sensitive animals to the bile formation processes were immature and old animals, affected by K2Cr2O7.
References
Experimental study of the influence of heavy metals on animals of different age groups / IM Trachtenberg, TK Korolenko, M. Kite [Et al.] // Labor hygiene, collections of 35. - 2004. - P. 158- 170.
Yztleuov MK homeostasis and pathology hromovay a/ MK Yztleuov. - Almaty, 2003. - 213 p.
Solohub LI Chromium in humans and animals. Biochemical, immunological and environmental aspects / LI Sologub, GL Antoniak, N. Babich. - Lviv: Yevrosvit, 2007. - 127 p.
VD Stefaniuk State of the secretory function of the stomach in patients with peptic ulcer disease and chronic ґastroduodenit, in contact with small concentrations chromium compounds according to professional status, age and sex / VD Stefaniuk // Practical Philosophy. medicine. - 2003 - 9 № 2. - P. 142-146.
Is hexavalent chromium carcinogenic via ingestion? A weight-of-evidence review / D. M. Proctor, J. M. Otani, B. L. Finley [et al.] // J. toxicol. environ. health. - 2002. - № 65. - P. 701-746.
N. Khomich cations Effect of chromium (VI) in activityenzymes of energy metabolism in hepatocytes animals / N. Khomich, N. Panas, G. Antonyak // Visn. Lviv. nat. Agrar. Univ. - 2010. - № 3. - C. 78-84.
Hexavalent chromium ingestion: biological markers of nephrotoxicity and genotoxicity / R. Hantson, A. Van Caenegem, I. Decordier [et al.] // Clin. toxicol. (Phila). - 2005 - 43, № 2. - P. 111-112.
Role of chromium (VI) in the chromium (VI) related free radical formation, dG hydrooxylation, and DNA damage / H. Lwo, Y. Cu, X. Shi [et al.] // J. inorg. biochem. - 1996 - 64, № 1. - P. 25-35.
Shapoval GS Mechanisms antioxidant protection of organisms in the forms of action aktyvn oxygen / GS Shapoval, V. Hromovaya // Ukr. Biochem. Zh. - 2003 - 75, № 2. - P. 5-13.
Guide for the care and use of laboratory animals: Eighth edition. The National Academies Press, Washington, DC. - 2011.
The method for determining the activity katalaz / MA Koroliuk, LI Ivanova, IG Mayorov [et al.] // Lab. case. - 1988. - № 1. - P. 16-19. 12. Lifshitz VM Byohymycheskye in analyz Clinic: Directory / VM Lifshitz, VI Sidelnikova. - 5th ed., Rev. and complement. - Moscow: Triada-X 2002. - 208 p.
Lapacho SN Statystycheskye methods in medykobyolohycheskyh Using the study with Excel / SN Lapacho, AV Chubenko, PN Babich. - K: Moryon, 2000. - 320 p.
The metabolic aspects prediction Chronic hepatitis outcomes vyrusnoho / E. I. Beloborodov, IV Savchenko, Beloborodov EV [et al.] // Klynich. medicine. - 2005 - 83, № 2. - P. 53-56.