Influence of apoptosis induced mesenchymal stem cells to dna fragmentation level and activity of sphingosine sitsemy under an experimental modeling of pathological processes
DOI:
https://doi.org/10.11603/mcch.2410-681X.2016.v0.i1.6124Abstract
During the studying the level of DNA fragmentation and free sphingosine in animals had been modeled acute renal failure, we obtained results which indicate stimulation ischemic process apoptotic activity in kidney tissue or 3, 7 and 14 day of study, which was confirmed by increased levels of the studied marker. Further use of mesenchymal stem cells cultured in apoptosis-induced environment near modeled pathological process led to the initial sharp rise in both fragmented DNA and free sphingosine in renal tissue on day 3, with a consequent reduction in their
concentrations to 14 days of the experiment almost to the figures obtained by us in the group of intact animals.
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