Malfunctions of the conjugated system “Restoring thiols –Nitrogen oxide” with acute cerebrovascular accident and possible correction
DOI:
https://doi.org/10.11603/mcch.2410-681X.2015.v17.i4.5687Keywords:
cerebrovascular accident, thiol-disulfide balance, thiotriazolin, angiolin, nitric oxide, glutathione system.Abstract
Experimental acute ischemic stroke was modeled by bilateral occlusion of the common carotid arteries in rats. Antioxidant system in the brain tissue was evaluated by the activity of key enzymes of thiol and disulfide indicators nitrosative stress. Simulation of acute ischemic accompanied by violation of the thiol-disulfide balance and increased nitrotyrosine levels, indicating that the development of oxidative and nitrosative stress in brain tissue. It is established that the use of thiol-containing antioxidants – Thiotriazoline and Angiolin set the highest possible ratio between the levels of reduced and oxidized thiol groups and glutathione, which indicates that the active mobilization of thioldisulfide system in the neutralization products of free-radical oxidation. Identified effects of the drugs used due to the presence in their structure of the thiol group, which contributes to the normalization of the glutathione system in conditions of oxidative stress.
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