EFFECT OF HOMOCYSTEINE ON THE TONE OF THE AORTA IN RATS WITH DIFFERENT THYROID STATUS
DOI:
https://doi.org/10.11603/mcch.2410-681X.2026.i1.15953Keywords:
hyperthyroidism; hypothyroidism; homocysteine; tone; aorta.Abstract
Introduction. Thyroid hormones affect the cardiovascular system directly via nuclear receptors and ion channels, or indirectly through the sympathetic nervous system. While thyroid hormones mechanisms are well-studied, the impact of thyroid hormones deficiency or excess on vascular sensitivity to homocysteine remains unclear. The aim was to evaluate in vitro the effect of homocysteine on aortic ring contractility under hypo- and hyperthyroidism conditions. Methods. 30 male rats were divided into: intact, hyperthyroid, and hypothyroid groups. Aortic contractility was assessed using a tensometric setup. Statistical analysis: Student’s t-test (p≤0.05). Results. The constrictive effect of homocysteine on the aorta significantly increased in mercazolil- induced hypothyroidism (EC50 was 24.8–39.3 % lower than control). Conversely, hyperthyroidism reduced the vasoconstrictor effect (EC50 was 22.8–37.2 % higher than control). Conclusions. Thyroid hormones modulate vascular sensitivity to homocysteine: hypothyroidism increases, while hyperthyroidism decreases the aortic constrictor response.
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Accepted 2026-03-01
Published 2026-04-28
