ANALYSIS OF THE FEATURES OF ENDOGENIC INTOXICATION AND STRUCTURAL CHANGES IN THE THYROID GLAND OF RATS IN CONDITIONS OF SIMULATED POSTRESECTION PORTAL HYPERTENSION
DOI:
https://doi.org/10.11603/mcch.2410-681X.2026.i1.15937Keywords:
thyroid organ; endotoxicosis; increased pressure in the portal vein, morphometry.Abstract
Introduction. The features of endogenous intoxication and morphological changes in the thyroid gland in hemodynamic disorders in the portal system have not been studied sufficiently. The Аim of the study – to analyze the features of endogenous intoxication and structural changes in the thyroid gland of rats under conditions of simulated postresection portal hypertension. Research Methods. Morphological and biochemical methods were used to study the thyroid gland of three groups of white rats: the first group – 15 control animals, the second – 30 rats with postoperative hypertension in the portal vein system, the third – 17 animals with postoperative portal hypertension. Complicated by multiple organ failure. Postresection portal hypertension was modeled by removing the left and right lateral lobes of the liver. The content of medium-weight molecules, erythrocyte intoxication index and the concentration of circulating immune complexes were determined in the blood serum. Morphometrically, the volumes of damaged endothelial cells in the arterial and venous beds, thymocytes, relative volume of parenchyma, stroma, stromal-parenchymal ratios, nuclear-cytoplasmic indices of endothelial cells of arteries, veins, and thymocytes were calculated on thyroid micropreparations. Quantitative values were statistically processed. Results and Discussion. It was established that resection of the left and right lateral lobes of the liver in white rats led to the occurrence of post-resection portal hypertension. At the same time, 36.1 % of animals developed multiple organ failure. Under conditions of simulated pathology, pronounced endotoxicosis was detected in the blood serum of rats, and significant pathomorphological changes in the structures of the thyroid gland were found in micropreparations. Endogenous intoxication and pathomorphology of the thyroid gland dominated in the combination of post-resection portal hypertension with multiple organ failure. The severity of endotoxicosis correlated with morphological changes in the thyroid gland. Conclusions. Removal of the right and left lateral lobes of the liver leads to postresection portal hypertension, increased endogenous intoxication and damage to the structures of the thyroid gland. The degree of increase in endotoxicosis and the severity of structural changes in the thyroid gland prevailed in the combination of postresection portal hypertension with multiple organ failure. Correlative relationships between indicators of endogenous intoxication and morphological changes in the structures of the thyroid gland have been identified the most pronounced correlation was between the erythrocyte intoxication index and the volume of damaged endotheliocytes of the thyroid vein (r = +0.66 ± 0.05).
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Accepted 2026-03-06
Published 2026-04-28
