STUDY OF THE INFLUENCE OF PHARMACEUTICAL FACTORS ON THE EFFICIENCY OF EXTRACTION FROM A GROUND-IVY HERB

Abstract

Introduction. Medicinal plant raw materials are an inexhaustible source of natural biologically active substances, therefore the study of new plant types and the creation of herbal medicines based on them is a relevant topic of scientific research.The Aim of the Study – is to study the influence of technological factors on the efficiency of extraction and recovery of biologically active substances from the ground-ivy herb.Research Methods. The objects of the research were extracts from ground-ivy herb obtained by maceration, maceration with stirring, fractional maceration and maceration with ultrasound. The quantitative content of the sum of phenolic compounds was determined by the spectrophotometric method in terms of gallic acid, the amount of flavonoids was determined by the spectrophotometric method in terms of rutin. Results and Discussion. The influence of factors such as extraction method, extractant concentration, degree of grinding of raw materials, raw materials: extractant ratio on the extraction of biologically active substances (extractive substances, flavonoids, phenolic compounds) from the ground-ivy herb was studied.Conclusions. Based on the conducted research, the influence of such technological factors as: the type of extraction, the nature and concentration of the extractant, the degree of grinding and the ratio of raw material: extractant on the extraction of active substances from the ground-ivy herb. Based on the desirability function, it was established that the maximum extraction of the sum of phenolic compounds, flavonoids and extractive substances is ensured by extraction using the maceration method with stirring, 75% ethanol when grinding the raw material to less than 2 mm at a ratio of raw material: extractant of 1:8.