PROGNOSTIC VALUE OF INTEGRAL HEMOCYTOMETRIC INDICES IN PATIENTS WITH HEMORRHAGIC STROKE
DOI:
https://doi.org/10.11603/mcch.2410-681X.2024.i2.14763Keywords:
hemorrhagic stroke, leukocytes, platelets, leukocyte-platelet indicesAbstract
Introduction. Changes in the cellular composition of the blood are a valuable source of information about the patient's condition and the severity of the disease. Recently, integral hemocytometric indices (IHIs), including the platelet-to-leukocyte ratio, have been used to assess the body's systemic response to injury. This is due to the fact that platelets play not only a hemostatic role but also actively participate in inflammatory reactions, interacting closely with various forms of leukocytes. Currently, the prognostic value of these indices has been identified in various pathologies, particularly in myocardial infarction, pulmonary embolism, and ischemic stroke.
The aim of the study – to identify the features of changes in platelet and leukocyte blood parameters and integral hemocytometric indices in patients with hemorrhagic stroke depending on the disease prognosis.
Research Methods. A total of 42 patients with hemorrhagic stroke were examined. Patients were divided into 2 groups: those who were discharged from the clinic after treatment (Group I) and those in whom the hemorrhagic stroke resulted in death (Group II). Leukocyte and platelet blood parameters were studied on the first day of the disease. Leukocyte (neutrophil-to-lymphocyte ratio, systemic inflammation response index) and platelet-leukocyte indices (neutrophil-to-platelet ratio, platelet-to-lymphocyte ratio, platelet-to-monocyte ratio) were calculated.
Results and Discussion. When studying the leukocyte and platelet blood parameters, only the absolute number of neutrophils was significantly higher in patients who died; the remaining parameters did not differ significantly between the two groups. Among the IHIs, the neutrophil-to-lymphocyte ratio, systemic inflammation response index and neutrophil-to-platelet ratio were significantly higher in patients who died in the acute phase of hemorrhagic stroke.
Conclusions. For predicting the course of hemorrhagic stroke, the integral assessment of blood parameters using leukocyte and platelet-leukocyte indices may be more effective than examining individual parameters of the complete blood count.
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