EFFECT OF GLUTAMATE-INDUCED OBESITY ON THE METABOLIC PROFILE OF THE LIVER AND CORRECTION BY MULTIPROBIOTIC OR NANOCRYSTALLINE CERIUM DIOXIDE
DOI:
https://doi.org/10.11603/mcch.2410-681X.2024.i1.14593Keywords:
МАРІЯ ТИХА, obesity, hepatic steatosis, multi-probiotic, nanocrystalline cerium dioxideAbstract
Introduction. Currently, there is no unidirectional formulation regarding the mechanisms of the pathogenesis of steatohepatosis and its connection with accompanying pathologies, which generally determines the relevance of research.
The aim of the study – to characterize the corrective effect of the multiprobiotic “Symbiter acidophilic” concentrated or nanocrystalline cerium dioxide on the formation of steatohepatosis induced by neonatal sodium glutamate administration.
Research Methods. The experiments were carried out on white non-linear male rats, the direction included the study of the mechanisms of development of steatohepatosis in rats for 16 weeks, which were administered monosodium glutamate in the neonatal period and the study of the structural and functional state of the liver in rats after neonatal administration of monosodium glutamate against the background of periodic administration of a multiprobiotic or nanocrystalline dioxide cerium.
Results and Discussion. It was established that neonatal sodium glutamate administration causes metabolic changes in 16-week-old rats, which are manifested in disproportionate accumulation of fat with the development of visceral obesity, dyslipidemia, and steatohepatosis. In rats, after neonatal administration of monosodium glutamate, lipid metabolism was disturbed, which was manifested in an increase in the concentration of triglycerides, total cholesterol, low and very low density lipoproteins and a decrease in the concentration of high density lipoproteins. Periodic administration of a multiprobiotic or nanocrystalline cerium dioxide to rats after neonatal sodium glutamate administration significantly normalized lipid metabolism indicators.
Conclusions. In rats injected with monosodium glutamate in the neonatal period, periodic use of the multiprobiotic “Symbiter acidophilic” concentrated or nanocrystalline cerium dioxide significantly restored the morpho-functional state of the liver, reduced the manifestations of oxidative stress and prevented the development of steatohepatosis, which indicates the antioxidant effect of these drugs and the possibility of their use for the prevention of steatohepatosis.
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