APPLICATION OF METAL NANOPARTICLE COMPOSITION FOR CORRECTION OF ENDOGENOUS INTOXICATION SYNDROME IN INDUCED CARCINOGENESIS UNDER CONDITIONS OF ISCHEMIC HEART INJURY
DOI:
https://doi.org/10.11603/mcch.2410-681X.2024.i1.14569Keywords:
Au/Ag/Fe nanoparticles, endogenous intoxication, middle mass molecules, erythrocyte intoxication index, induced colon adenocarcinoma, isoproterenol-induced myocardial injuryAbstract
Introduction. Endogenous intoxication syndrome is a nonspecific condition characteristic of many diseases, including cancer and cardiovascular diseases. Considering the numerous positive properties of nanomaterials in correcting pathological processes, it is advisable to study their effect on the parameters of endotoxemia and the ability of nanometals to work as a composition.
The aim of the study – to determine the effect of Au/Ag/Fe nanometal composition on endotoxemia parameters in induced carcinogenesis under conditions of ischemic heart injury.
Research Methods. The study was performed on 50 white male outbred rats. The animals were divided into five groups: I – intact; II – animals with modeled ischemic myocardial injury; III – animals with ischemic myocardial injury, which were administered with the composition of Au/Ag/Fe nanoparticles; IV – animals with modeled carcinogenesis under conditions of ischemic myocardial injury; V – animals with modeled carcinogenesis under conditions of ischemic myocardial injury, which were administered with the composition of Au/Ag/Fe nanoparticles. The degree of endogenous intoxication was assessed by changes in the erythrocyte intoxication index (EII), the content of medium mass molecules (MMM238, MMM254, MMM260, MMM280) and their indices.
Results and Discussion. Under the conditions of combined pathology, the content of all fractions of MMM reached its maximum compared to other experimental groups and significantly (p<0,001) exceeded that of the intact group of animals. The use of the nanoparticle Au/Ag/Fe composition to correct endogenous intoxication syndrome in induced carcinogenesis under conditions of ischemic myocardial injury contributed to a significant decrease in the concentrations of all MMM fractions. Thus, the concentration of MMM280 in the fifth experimental group decreased by 1.73 times (p<0.001) compared with the same indicator of the fourth group; MMM254 – by 1.53 times (p<0.001); MMM238 – by 1.73 times (p<0.001); MCM260 – by 1.26 times (p<0.01). This effect may be due to the antimicrobial, anti-inflammatory and probiotic properties of the composition of metal nanoparticles. EII in animals with dual pathology significantly (p<0.001) exceeds the intact value by 2.65 times, while the use of Au/Ag/Fe composition contributed to a decrease in this parameter by 1.29 times (p<0.001).
Conclusions. The use of the Au/Ag/Fe nanometal composition contributes to a statistically significant reduction in the concentrations of blood plasma toxicity indicators, which leads to an improvement in the body’s general condition of experimental animals with dual pathology.
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