SELECTION OF EXCIPIENTS FOR OBTAINING CAPSULATION MASS WITH DRY EXTRACT OF MARIGOLDS
DOI:
https://doi.org/10.11603/mcch.2410-681X.2023.i4.14382Keywords:
mass for encapsulation, dry extract, marigolds, excipients, capsulesAbstract
Introduction. Plant raw materials are widely used to prevent and treat many diseases. An in-depth study of the flowers, leaves and herbs of Tagetes lucida and the creation of medicines based on them is an interest. It is known that, in addition to active pharmaceutical ingredients (API), various groups of auxiliary substances (excipients) are included in the composition of ready-made medicinal products. Increasing the accuracy of the API dosage, improving absorption and solubility of the drug, improving stability (extend the shelf life) and promotion better patient tolerance and perception of the drug, including its appearance and taste is a main purpose of adding an excipient to the drug composition.
The aim of study – to select auxiliary substances for creating capsules based on the dry extract of the marigold herb Tagetes lucida.
Research Methods. The influence of 9 excipients on the technological properties of the masses for encapsulation based on the dry extract of marigolds and the rationale for choosing the best excipients in the development of the encapsulated drug using the method of mathematical planning of the experiment were studied.
Results and Discussion. At the first stage of the experiment, the morphometric and pharmacotechnological parameters of the dry extract of the marigold herb Tagetes lucida were studied. In our works, we considered the selection of excipient leaders according to their properties and functional purpose for obtaining powder mass with the dry extract of the marigold herb Tagetes lucida. In addition, the main technological aspects were covered, which consisted in choosing the best combinations of excipients and in the method of introducing the dry extract into the powder mass.
The study and selection of excipients in the development of a drug based on dry extract of marigolds in the form of capsules were carried out.
Conclusions. It was found that to obtain a mass for encapsulation with the necessary pharmaco-technological indicators, it is advisable to use the following combination of excipients: Lycatab PGS, compri Zucker and Prosolv.
References
Kashif, M., Bano, S., Naqvi, S., Faizi, S., Lubna, M., Mesaik, A., Shamsuddin Azeemi, K., & Farooq, A. (2015). Cytotoxic and antioxidant properties of phenolic compounds from Tagetes patula flower. Pharm. Biol., 53 (5), 672-681. https://doi.org/10.3109/13880209.2014.936471. DOI: https://doi.org/10.3109/13880209.2014.936471
Suk-Yee Li, Frederic K.C. Fung, Zhong Jie Fu, David Wong, Henry H.L. Chan, Amy C.Y. Lo. (2012). Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro studies. Investigative Ophthalmology and Visual Science., 53(10), 5976-5984. https://doi.org/10.1167/iovs.12-10007. DOI: https://doi.org/10.1167/iovs.12-10007
Karimian , P., Kavoosi, G., & Amirghofran, Z. (2014). Anti-oxidative and anti-inflammatory effects of Tagetes minuta essential oil in activated macrophages. Asian Pacific Journal of Tropical Biomedicine., 4(3), 219-227. https://doi.org/10.1016/s2221-1691(14)60235-5. DOI: https://doi.org/10.1016/S2221-1691(14)60235-5
Rodov, V., Vinokur, Y., Gogia, N., & Chkhikvishvili, I. (2010). Hydrophilic and lipophilic antioxidant capacities of Georgian spices for meat and their possible health implications. Georgian Medical News., 179, 61-66.
Marchyshyn, S.M., Berdei, T.S., Kozachok, S.S., & Demydiak, O.L. (2013). Determination of flavonoids and hydroxycinnamic acids in Tagetes erecta L., Tagetes patula L. and Tagetes tenuifolia Cav. HPLC method. Journal of Siberian Medical Sciences, 6 [in Ukrainian].
Slobodianiuk, L., Budniak, L., & Marchyshyn, S. (2021). Determination of amino acids content of the Tagetes lucida Cav. by GC/MS. Pharmacia, 68(4), 859-867. DOI: https://doi.org/10.3897/pharmacia.68.e73325
Chkhikvishvili, I., Sanikidze , T., Gogia , N., Enukidze , M., Machavariani, M., Kipiani, N., Vinokur, Y., & Rodov, V. (2016). Constituents of French Marigold (Tagetes patula L.) Flowers Protect Jurkat T-Cells against Oxidative Stress. Oxid. Med. Cell Longev, 4216285. https://doi.org/10.1155/2016/4216285. DOI: https://doi.org/10.1155/2016/4216285
Zarivna, N.O. (2023). Study of the optimal composition of capsule mass with essential oil of common thyme in the development of hard capsules. Medical and clinical chemistry, 25 (3), 123-128 [in Ukrainian].
Zarivna, N.O. (2014). The choice of excipients for obtaining a powder mass with essential oil of common thyme in the development of hard capsules. Achievements of clinical and experimental medicine, 2, 69-72 [in Ukrainian].
Zaikov, S.V., Bohomolov, A.Ye., Hritsova, N.A., & Veselovskyi, L.V. (2023). Hypersensitivity to drug excipients. Literature review. Asthma and Allergy, 1, 51-62. https://doi.org/10.31655/2307-3373-2023-1-51–62 [in Ukrainian]. DOI: https://doi.org/10.31655/2307-3373-2023-1-51-62
(2014). State Pharmacopoeia of Ukraine: in 3 volumes. State enterprise “Ukrainian Scientific Pharmacopoeia Center for the Quality of Medicinal Products”. 2nd edition. Kharkiv [in Ukrainian].
Rowe, R.C., Sheskey, P.J., & Quinn, M.E. (2009). Handbook of Pharmaceutical Excipients. 6 Ed. London.
Hroshovyi, T.A, Martsenyuk, V.P., Kucherenko, L.I., Vronska, L.V., & Huryeyeva, C.M. (2008). Mathematical planning of an experiment when conducting an experiment of scientific research in pharmacy. Ternopil: Ukrmedknyha [in Ukrainian].
Hroshovyi1, T.A., Demchuk, M.B., Belei, N.M. Naida, Yu.V., & Pavliuk, B.V. (2020). The design of the experiment when conducting research on the creation of tablet medicines. Pharmaceutical journal, 2, 101-109 [in Ukrainian].
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