HORMONAL PROFILE CHANGES COMPARISON IN INFERTILE WOMEN WITH LEIOMYOMA AND CHRONIC ENDOMETRITIS DEPENDING ON THE TREATMENT SCHEME

Authors

  • S. V. Khmil І. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY MEDICAL CENTER “CLINIC OF PROFESSOR STEFAN KHMIL”, TERNOPIL
  • N. Ya. Petryshyn І. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY MEDICAL CENTER “CLINIC OF PROFESSOR STEFAN KHMIL”, TERNOPIL

DOI:

https://doi.org/10.11603/mcch.2410-681X.2023.i3.14161

Keywords:

infertility, leiomyoma, chronic endometritis, assisted reproductive technologies, in vitro fertilization, sex hormones, treatment

Abstract

Introducton. Infertility nowadays is a current medical and social issue. Assisted reproductive technologies is currently the most effective method of infertility treatment. Some scientific studies report about the correlation between uterus fibroids and chronic endometritis. The negative effect of these pathologies on women's reproductive health has been proven, causing dysfunction of endometrial receptivity and as a result, infertility, repeated implantation failure in IVF protocols, miscarriages and premature birth.

The aim of the study – to investigare the influence of different treatment schemes on the hormonal profile in infertile patients with leiomyoma and chronic endometritis comorbidity.

Research Methods. Clinical examination and comparative analysis of clinical and anamnestic data of 105 infertile women with uterine leiomyoma and chronic endometritis comorbidity. The patients were divided into two research groups depending on the proposed treatment scheme for chronic endometritis and a separately formed a control group.

Results and Discussion. The modified treatment scheme resulted in a significant FSH level decreasing, an increasing of the FSH/LH ratio, decreasing of the progesterone level on 2–3 days of the menstrual cycle and an increasing of its concentration on 21st day. In the group of the modified treatment scheme of chronic endometritis with pregravid preparation the number of retrieved oocytes and blastocysts, as well as pregnancy rate and childbirth were probably higher compared to the group of standard therapy.

Conclusions. Considering the important influence of sex hormones on the process of implantation and pregnancy, which is often changed in patients with chronic endometritis and uterine leiomyoma, monitoring and correction of the hormonal profile in infertile patients are necessary. This helps to choose the optimal treatment method.

References

World Health Organization. (2023). Infertility prevalence estimates: 1990–2021.

Eskew, A.M., & Jungheim, E.S. (2017). A history of developments to improve in vitro fertilization. Missouri Medicine, 114 (3), 156.

Kabodmehri, R., Etezadi, A., Sharami, S.H., Ghanaei, M.M., Hosseinzadeh, F., Heirati, S.F.D., & Pourhabibi, Z. (2022). The association between chronic endometritis and uterine fibroids. Journal of Family Medicine and Primary Care, 11(2), 653. DOI: https://doi.org/10.4103/jfmpc.jfmpc_1470_21

Giuliani, E., As-Sanie, S., Marsh, E.E. (2020). Epidemiology and management of uterine fibroids. Int. J. Gynecol. Obstet., 149, 3-9. DOI: https://doi.org/10.1002/ijgo.13102

Chen, Y., Lin, M., Guo, P., Xiao, J., Huang, X., Xu, L., ... & Tan, X. (2021). Uterine fibroids increase the risk of hypertensive disorders of pregnancy: a prospective cohort study. Journal of Hypertension, 39(5), 1002. DOI: https://doi.org/10.1097/HJH.0000000000002729

Ma, J., Gao, W., & Li, D. (2023). Recurrent implantation failure: A comprehensive summary from etiology to treatment. Frontiers in Endocrinology, 13, 1061766. DOI: https://doi.org/10.3389/fendo.2022.1061766

AlAshqar, A., Reschke, L., Kirschen, G.W., & Borahay, M.A. (2021). Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies. Biology of Reproduction, 105(1), 7-31. DOI: https://doi.org/10.1093/biolre/ioab054

Gleason, J.L., Thoma, M. E., Zukerman Willin­ger, N., & Shenassa, E.D. (2022). Endometriosis and uterine fibroids and their associations with elevated C-reactive protein and leukocyte telomere length among a representative sample of US women: data from the National Health and Nutrition Examination Survey, 1999–2002. Journal of Women's Health, 31(7), 1020-1028. DOI: https://doi.org/10.1089/jwh.2021.0044

Armanini, D., Sabbadin, C., Donà, G., Bordin, L., Marin, L., Andrisani, A., & Ambrosini, G. (2018). Uterine fibroids and risk of hypertension: implication of inflam­mation and a possible role of the renin-angiotensin-aldosterone system. The Journal of Clinical Hyper­tension, 20(4), 727. DOI: https://doi.org/10.1111/jch.13262

Orciani, M., Caffarini, M., Biagini, A., Lucarini, G., Delli Carpini, G., Berretta, A., ... & Ciavattini, A. (2018). Chronic inflammation may enhance leiomyoma deve­lopment by the involvement of progenitor cells. Stem Cells International, 2018. DOI: https://doi.org/10.1155/2018/1716246

Wu, D., Kimura, F., Zheng, L., Ishida, M., Niwa, Y., Hirata, K., ... & Murakami, T. (2017). Chronic endometritis modifies decidualization in human endometrial stromal cells. Reproductive Biology and Endocrinology, 15(1), 1-10. DOI: https://doi.org/10.1186/s12958-017-0233-x

Hirata, K., Kimura, F., Nakamura, A., Kitazawa, J., Morimune, A., Hanada, T., ... & Murakami, T. (2021). Histological diagnostic criterion for chronic endometritis based on the clinical outcome. BMC Women's Health, 21(1), 1-11. DOI: https://doi.org/10.1186/s12905-021-01239-y

Ota, K., Takahashi, T., Mitsui, J., Kuroda, K., Hiraoka, K., & Kawai, K. (2022). A case of discrepancy between three ERA tests in a woman with repeated implantation failure complicated by chronic endo­metritis. BMC Pregnancy and Childbirth, 22(1), 1-7. DOI: https://doi.org/10.1186/s12884-022-05241-6

Lessey, B.A., & Young, S.L. (2019). What exactly is endometrial receptivity? Fertility and Sterility, 111(4), 611-617. DOI: https://doi.org/10.1016/j.fertnstert.2019.02.009

Moustafa, S., & Young, S.L. (2020). Diagnostic and therapeutic options in recurrent implantation failure. F1000Research, 9. DOI: https://doi.org/10.12688/f1000research.22403.1

Alan, B., Genç, A.S., & Erbaş, O. (2023). Innovative Approach: Platelet-Rich Plasma and In Vitro Fertilization. Journal of Experimental and Basic Medical Sciences, 4(2), 110-115.

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Published

2023-10-27

How to Cite

Khmil, S. V., & Petryshyn, N. Y. (2023). HORMONAL PROFILE CHANGES COMPARISON IN INFERTILE WOMEN WITH LEIOMYOMA AND CHRONIC ENDOMETRITIS DEPENDING ON THE TREATMENT SCHEME. Medical and Clinical Chemistry, (3), 134–143. https://doi.org/10.11603/mcch.2410-681X.2023.i3.14161

Issue

No. 3 (2023)

Section

ORIGINAL INVESTIGATIONS

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