INFLUENCE OF FNDC5 GENE POLYMORPHISMS ON THE PREDICTION TO THE DEVELOPMENT OF OBESITY IN WOMEN OF MATURE AGE PERIOD II

Authors

  • Yu. M. Panchenko NATIONAL UNIVERSITY OF UKRAINE ON PHYSICAL EDUCATION AND SPORT, KYIV
  • S. B. Drozdovska NATIONAL UNIVERSITY OF UKRAINE ON PHYSICAL EDUCATION AND SPORT, KYIV

DOI:

https://doi.org/10.11603/mcch.2410-681X.2023.i3.14129

Keywords:

myokines, irisin, gene polymorphism, obesity, physical activity, skeletal muscles, health-enhancing fitness

Abstract

 Introduction. In recent studies it has been shown that the implementation of the health-enhancing effect of physical exercises in obesity occurs due to the action of the myokine irisin on adipocytes. Irisin is formed by cleavage from the membrane protein FNDC5. Polymorphisms of this gene can determine sensitivity to insulin and the tendency to develop obesity, the effectiveness of reducing body weight under the influence of exercise.

The aim of the study – to determine the relationship between variants of the FNDC5 gene and the predisposition to obesity, the effectiveness of the influence of various fitness programs on weight loss, to establish the possibility of using polymorphic variants of the gene as a marker of the effectiveness of the use of fitness programs.

Research Methods. 39 women with I–III degrees of obesity took part in a 12-week health fitness program with aerobic training. At the beginning and after the program, anthropometric and biochemical blood parameters were measured (insulin, glucose, HOMA, high and low density lipoproteins, cholesterol, triglycerides, irisin, leptin, hormones). 3 polymorphisms of the FNDC5 gene were determined by scanning microarrays with the DNA of the buccal epithelium.

Results and Discussion. The analysis of the influence of polymorphisms of the FNDC5 gene on the predisposition to obesity and the search for associations of these polymorphisms with the anthropometric parameters of obese women was performed with the help of ANOVA and allowed us to clarify that the BMI of individuals with the G/G genotype significantly exceeds the same indicator in women with the T/T and T/G genotype (p=0.0012). T/T at rs1683598 of the FNDC5 gene promotes an increase in insulin levels in the blood of obese women and the HOMA-IR index. The association of FNDC5 gene polymorphisms with the level of irisin in the blood plasma of obese women and the effectiveness of reducing body weight and insulin sensitivity under the influence of a 3-month health fitness program was not established in our work.

Conclusions. The G-allele and G/G-genotype of the T/G-polymorphism of the FNDC5 gene (rs16835198) are associated with increased BMI and contribute to the obesity predisposition. The T/G polymorphism of the FNDC5 gene can be considered as a molecular genetic marker of obesity. Women, carriers of the T/T genotype rs1683598 polymorphism of the FNDC5 gene are characterized by an increased level of insulin in fasting blood and an increased level of the HOMA-IR index.

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Published

2023-10-27

How to Cite

Panchenko, Y. M., & Drozdovska, S. B. (2023). INFLUENCE OF FNDC5 GENE POLYMORPHISMS ON THE PREDICTION TO THE DEVELOPMENT OF OBESITY IN WOMEN OF MATURE AGE PERIOD II. Medical and Clinical Chemistry, (3), 36–42. https://doi.org/10.11603/mcch.2410-681X.2023.i3.14129

Issue

No. 3 (2023)

Section

ORIGINAL INVESTIGATIONS

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