INFLUENCE OF COMBINED ACTION OF ZINC OXIDE NANOPARTICLES AND HERBICIDE GLYPHOSATE ON THE STATE OF HUMORAL LINK IMMUNE SYSTEM
DOI:
https://doi.org/10.11603/mcch.2410-681X.2022.i4.13574Keywords:
nano-ZnO, glyphosate, immunoglobulinsAbstract
Introduction. Nanotechnology today is the most promising direction in the development of world science. Nanomaterials have caused a step forward in many industries and are used in our overall life. Due to their unique properties, nanoparticles are widely used in scientific research, industry and medicine. With everyday increase in the pace of use of nanomaterials, less attention is paid to the possible negative effect of nanoparticles on the health of people and environmental safety as a whole. The capability of nanoparticles to increase the transport of chemicals and drugs into cells and through the body barriers provides the possibility of the potentiating of chemical contaminants toxicity in case of their simultaneous intake into the body.
The aim of the study – to investigate the ability of zinc oxide nanoparticles and chemical toxicant herbicide glyphosate to cause changes in the state of humoral immune system
Research Methods. Suspension of ZnO nanoparticles (0.5 ml) at a dose of 100 mg/kg and glyphosate (in the form of herbicide roundup) at a dose of 250 mg/kg of body weight were administered intragastrically to male rats for 14 days. The toxicants were administered simultaneously and separately. Circulating immune complexes and classes of immunoglobulins А, М, G were measured in rat blood plasma.
Results and Discussion. It was established that under the influence of zinc oxide nanoparticles, the studied indicators did not reliably differ from the control indicators. The administration of glyphosate to rats caused significant changes of indices immunoglobulins G and circulating immune complexes. However, the maximal changes of the parameters were evidenced in the group of animals that were co-administered with zinc oxide nanoparticles and glyphosate. In this case, activities of circulating immune complexes and immunoglobulins blood significantly changed compared to the similar indicators in the group of animals, which were administered with the chemical toxicant only.
Conclusion. Zinc oxide nanoparticles enhance the negative toxic effects of herbicide glyphosate. Carbon nanotubes enhance the negative toxic effects of tetrachloromethane.
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