CONTENT OF CYTOKINES IN SALIVA IN ALVEOLITES AFTER ATYPICAL REMOVAL OF WISDOM TEETH
DOI:
https://doi.org/10.11603/mcch.2410-681X.2022.i2.13206Keywords:
interleukin 6, atypical tooth extractionAbstract
Introduction. A common inflammatory complication after an atypical wisdom tooth removal operation is alveolitis (local osteitis), which occurs in 14–35 % of such operations. Surgical intervention and the infection play the role of pathogenetic factors in the development of alveolitis. For the prevention and assessment of the effectiveness of the treatment of this complication, a set of laboratory indicators that reflect the course of inflammation is proposed. At the same time, there is not enough information about the content of key pro-inflammatory cytokines of local importance.
The aim of the study – to conduct a study of the content of interleukin 1 β and interleukin 6 in the saliva of patients after atypical removal of wisdom teeth.
Research Methods. Clinical and laboratory examination of patients with alveolitis after wisdom tooth removal. The concentration of interleukins 1β and 6 was determined by ELISA.
Results and Discussion. The concentration of IL-1β in saliva in the group of patients before surgical intervention to remove the impacted tooth was probably 11.6 times higher, and the concentration of IL-6 was 13 times higher compared to the indicator in healthy individuals. After surgery, on the 3rd day, the level of interleukin IL-1β increased by 6.7 times, IL-6 – by 1.6 times compared to the preoperative level. On postoperative day 7, IL-1β decreased 3.6-fold and IL-6 decreased 2-fold compared to day 3, but remained higher compared to preoperative and control levels.
Conclusions. In patients with retinized 8 teeth, an increased level of pro-inflammatory cytokines IL-1β and IL-6 in saliva was found, which indicates the presence of chronic inflammation. After the removal of the wisdom tooth, a significant increase in the concentration of the studied cytokines in saliva was found, which were indicators of activation of the monocyte-macrophage system. On the basis of a comprehensive assessment of the clinical condition and the study of cytokines, it was established that the level of IL-1β and IL-6 in saliva significantly increases in patients with alveolitis (local osteitis).
References
Kuzniak, N.B., Tkachyk, S.V., Kushnir, O.L., & Tryfanenko, S.I. (2014). Modern methods of treatment of alveolitis. Clinical Dentistry, (4), 45-48 [in Ukrainian].
Roshka, Yu.O., Horytskyi, Ya.V., & Hahen, O.Yu. (2014). Alveolitis: current state of the problem. Clinical Dentistry, (2), 53-56 [in Ukrainian].
Sayed, N., Bakathir, A., Pasha, M., & Al-Sudairy, S. (2019). Complications of Third Molar Extraction: A retrospective study from a tertiary healthcare centre in Oman. Sultan Qaboos University Medical Journal, 19 (3), e230.
Candotto, V., Oberti, L., Gabrione, F., Scarano, A., Rossi, D., & Romano, M. (2019). Complication in third molar extractions. Journal of Biological Regulators and Homeostatic Agents, 33 (3 Suppl. 1), 169-172.
Carvalho, R.W, & do Egito Vasconcelos, B.C. (2011). Assessment of factors associated with surgical difficulty during removal of impacted lower third molars. J. Oral Maxillofac. Surg., 69 (11), 2714-2721.
Deliverska, E.G., & Petkova, M. (2016). Complications after extraction of impacted third molars-literature review. Journal of IMAB–Annual Proceeding Scientific Papers, 22 (3), 1202-1211.
Pankevych, A.I., Kolisnyk, I.A., & Hohol, A.M. (2019). Differentiated approach to the surgical extraction of wisdom teeth. Ukrainian Dental Almanac, (4), 24-28, 4, 24-28.
Nunn M., Fish M., & Garcia, R. (2013). Retained Asymptomatic third molars and risk for second molar pathology. J. Dent. Res., 92 (12), 1095-1099.
Ayhan, M., Senen, D., & Gorgu M. (2011). Multiple atrophies following tooth extraction. Aesthetic. Plast. Surg., 25 (6), 457-462.
Tryfanenko, S.I., & Hrynkevych, L.H. (2016). Current treatment of alveolitis jaws. Literature review. Euro-American Scientific Cooperation, 12, 55-61 [in Ukrainian].
Khomych, N.M., & Ohonovskyi, R.Z. (2016). Interleukins as a marker of imflammation of postoperative period of third molars surgery. Buk. Med. Herald, 20, 1 (77), 173-175 [in Ukrainian].
Amin, M.F., Meidyawati, R., Djamil, M.S., & Latief, B.S. (2019). Inflammatory cytokine serum levels in sockets following extraction of teeth with apical periodontitis. Journal of International Dental and Medical Research, 12 (1), 129-132.
Shetty, L., Gangwani, K., Londhe, U., Bharadwaj, S., Bakri, M. M. H., Alamoudi, A., ... & Testarelli, L. (2022). Comparison of the C-reactive protein level and visual analog scale scores between piezosurgery and rotatory osteotomy in mandibular impacted third molar extraction. Life, 12 (6), 923.
Bernadi, W., Hardianto, A., Yuza, A.T., & Harlina, E. (2021). Efficacy differences of Queen’s crepe-myrtle (Lagerstroemia speciosa) and aloe vera extract on the interleukin-6 and osteoblast levels in the healing process of alveolar osteitis. Padjadjaran Journal of Dentistry, 33 (2), 109-116.
Øyri, H., Jensen, J.L., Barkvoll, P., Jonsdottir, O.H., Reseland, J., & Bjørnland, T. (2021). Incidence of alveolar osteitis after mandibular third molar surgery. Can inflammatory cytokines be identified locally? Acta Odontologica Scandinavica, 79 (3), 205-211.
Algayer, E.C., Mioso, F.V., & Thereza-Bussolaro, C. (2022). Leukocyte and platelet-rich fibrin uses in third molar surgery. Craniofacial Research Connection Journal, 2 (1), 52-61.
Lapovets, L.Ie., Akimova, V.M., Lebed, H.B. (2022). Laboratorna imunolohiia. Posibnyk. Lviv: Magnoliia [in Ukrainian].
Mamchych, T., Olenko, M., Osypchuk, V., Shportiuk A. (2006). Statistical data analysis with the STATISTICA package. Drohobych: Vidrodzhennia [in Ukrainian].
Rakhshan, V. (2018). Common risk factors of dry socket (alveolitis osteitis) following dental extraction: A brief narrative review. Journal of Stomatology, Oral and Maxillofacial Surgery, 119 (5), 407-411.
Hotsko, Yu.M., & Lapovets, L.Ye. (2018). The content of interleukins in oral fluid of patients with non-removable metal ceramic prostheses. Ukrainian Dental Almanakh, (4), 27-31 [in Ukrainian].
Sudowe, S. (2013). Zytokine regulieren Qualität der Immunantwort. Allergo Journal, 22 (3), 166-167.
Alomaym, A.A., Aldohan, M.F.M., & Alkurdi I.F. (2019). Necessity of antibiotics to reduce inflammatory complications after third molar extractions: A prospective study. Journal of Pharmacy & Bioallied Sciences, 11 (Suppl. 1), 13-22.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Medical and Clinical Chemistry
This work is licensed under a Creative Commons Attribution 4.0 International License.
