EFFECT OF LIVER METABOLISM IN ADOLESCENTGIRLS WITH OBESITY AND NON-ALCOHOLIC FAT LIVER DISEASE ON BASAL ANDROGENIC PROFILE
DOI:
https://doi.org/10.11603/mcch.2410-681X.2020.i4.11727Keywords:
girls, sexual development, non-alcoholic fatty liver disease, obesity, hepatic metabolism, hyperandrogenism, menstrual healthAbstract
Introduction. In the literature, there are sporadic data on the functional state of the liver in adolescent girls with obesity and non-alcoholic fatty liver disease (NAFLD) and its effect on sexual development.
The aim of the study – to learn the features of the functional state of the liver in pubertal girls with non-alcoholic fatty liver disease and obesity and to assess the relationship with the formation of hyperandrogenic states.
Research Methods. 120 girls aged 12–17 years with NAFLD and obesity, as well as 180 girls of the control group were under observation. Comprehensive examination included collection of anamnesis, anthropometry, clinical and biochemical blood tests, ultrasound and computed tomography of the abdominal cavity, assessment of clinical and biochemical hyperandrogenism, menstrual health.
Results and Discussion. In girls with NAFLD and obesity, disorders of carbohydrate, lipid, and purine metabolism were revealed against the background of increased transferases. Androgen-dependent dermopathy was registered in 51.67 % of girls. A hirsute score of more than 12 points on the Ferriman-Gallway scale was found in 37.50 % of cases, in the range from 8 to 11 points – in 44.17 %, from 0 to 7 points – in 18.33 %. Girls of puberty with NAFLD and obesity were distinguished by an increased basal profile of peripheral blood androgens. The presence of insulin resistance and hyperandrogenism in girls with NAFLD and obesity in the study group led to the development of menstrual disorders during puberty: oligomenorrhea developed in 62.50% of cases, amenorrhea in 27.50 %, heavy menstruation bleeding in 10.00 %, 14.17 % – dysmenorrhea.
Conclusions. In adolescent girls with NAFLD and obesity, disorders of hepatic metabolism provoke the development of clinical and biochemical hyperandrogenism, which is the basis for disorders of sexual development and the formation of abnormal changes in menstrual health in girls of puberty.
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