PECULIARITIES OF CARBOHYDRATE AND LIPID METABOLISM IN PREMENOPAUSAL WOMEN WITH AUTOIMMUNE HYPOTHYROIDISM
DOI:
https://doi.org/10.11603/mcch.2410-681X.2020.v.i3.11544Keywords:
autoimmune thyroiditis, hypothyroidism, women, premenopausal age, correlations, dyslipidemia, insulin resistanceAbstract
Introduction. Thyroid dysfunction (TD) is considered as a common endocrine disease in the structure of which prevails hypothyroidism (HT). In most cases, HT is a consequence of autoimmune thyroiditis (AIT), which is most common in women. The increase of thyroid-stimulating hormone correlates with the parameters of the metabolic syndrome, which increases cardiovascular events and mortality.
The aim of the study – to investigate the correlations between thyroid-stimulating hormone (TSH), thyroid hormones and antibodies to thyroperoxidase (ATPO) with carbohydrate-lipid parameters in premenopausal women with autoimmune hypothyroidism.
Research Methods. 146 premenopausal women with HT were examined. All women underwent anthropometric, general clinical, biochemical examinations, including determination of lipid metabolism, hydrocarbon metabolism and assessed the functional status of the thyroid gland by determining the level of TSH, free thyroxine (BT4), free triiodothyronine (BT3) and ATPO. The results of the research were analyzed by the method of variation statistics using the program STATISTICA 12 (“Statsoft”, USA).
Results and Discussion. We found that the level of TSH and ATPO were characterized by a direct correlation of moderate strength with total cholesterol, triglycerides, low-density lipoprotein, atherogenic factor. We found that TSH and ATPO levels were characterized by a direct correlation of moderate strength with total cholesterol, triglycerides, low-density lipoprotein, atherogenic factor, and fT4 and fT3 were characterized by an inverse relationship. Were established significantly positive correlations of the mean strength of body mass index and HOMA-IR insulin resistance index with TSH and ATPO and negative correlations of average force with fT4 and fT3. A positive correlation was found between body mass index and HOMA-IR insulin resistance index with levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, atherogenic factor, and a negative correlation with high-lipoprotein cholesterol.
Conclusion. The study of correlations between carbohydrate and lipid metabolism in premenopausal women with autoimmune hypothyroidism is a relevant and promising area for studying the mechanisms of development of metabolic syndrome and its correction. Hormone replacement therapy with levothyroxine sodium in women with autoimmune hypothyroidism is insufficient to achieve the target levels of basic metabolic parameters.
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