RESEARCH OF ANTI-INFLAMMATORY ACTIVITY OF ARTEMISIA ABSINTHIUM L. AND ARTEMISIA VULGARIS L. EXTRACTS UNDER CONDITIONS OF THE PATHOLOGY OF DIFFERENT GENESIS
DOI:
https://doi.org/10.11603/mcch.2410-681X.2020.v.i2.11365Keywords:
anti-inflammatory effect, Artemisia absinthium L., Artemisia vulgaris L., carrageenan edema, formalin edemaAbstract
Introduction. Artemisia genus species are used in medicine for centuries. They have appetizing, anthelmintic, bactericidal, choleretic and anti-inflammatory effects. Their activity is caused by different groups of biologically active compounds.
The aim of the study – to learn the anti-inflammatory effect of Artemisia absinthium L. and Artemisia vulgaris L. extracts using carrageenan and formalin models of edema.
Research Methods. To determine the anti-inflammatory effect of Artemisia absinthium L. and Artemisia vulgaris L. herb extracts under the pathology of different genesis, two techniques were used: models of carrageenin and formalin edema (aseptic inflammation). They are recommended by the State Expert Center of the Ministry of Health of Ukraine for preclinical studies and for research of anti-exudative activity. The study and analysis of the obtained experimental data were performed in comparison with non-steroidal anti-inflammatory drug – sodium diclofenac and with quercetin.
Results and Discussion. It was found that a comparative study of the anti-inflammatory effect of Artemisia L. herb extracts in conditions of carrageenan edema, which is characterized by cyclooxygenase way of inflammation, Artemisia absinthium L. and Artemisia vulgaris L. extracts showed anti-exudative effect throughout the experiment. The best suppression of edema was observed during fifth hour since the introduction of the phlogogenic agent. It reveals the effect of Artemisia absinthium L. and Artemisia vulgaris L. extracts on inflammatory mediators – prostaglandins. In condition of the formalin edema, membrane protein degradation develops and inflammatory mediators, in particular prostaglandins, are released.
Conclusions. We have established a pronounced anti-inflammatory effect of Artemisia absinthium L. and Artemisia vulgaris L. extracts, which affect the mediators of inflammation – prostaglandins, and can be used as anti-inflammatory agents in conditions of the inflammatory processes of the pancreas and gall bladder.
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