INFLUENCE OF THE N-ACETYLGLUCOSAMINE AND QUERCETIN COMBINATION IN THE INJECTABLE DOSAGE FORM ON THE COURSE OF ISCHEMIC ACUTE KIDNEY INJURY IN RATS
DOI:
https://doi.org/10.11603/mcch.2410-681X.2019.v.i3.10554Keywords:
N-acetylglucosamine, quercetin, injectable dosage form, acute kidney injuryAbstract
Introduction. Optimization of the treatment of acute kidney injury (AKI) is an important medical and pharmaceutical problem. AKI is a common complication not only of kidney diseases, but also of various treatment methods. Mortality caused by AKI reaches 80 % in some groups of patients. Therefore, the search for effective agents for AKI treatment is an important task of modern experimental pharmacology. A promising approach in the solution of this problem may be the implementation of pharmaceutical combination of flavonoid quercetin and amino sugar N-acetylglucosamine in injectable dosage form.
The aim of the study – experimental study of the efficacy of N-acetylglucosamine and quercetin combination in injectable dosage form under the condition of ischemic AKI.
Research Methods. Studies were performed on a model of ischemic AKI in rats, which was induced by total occlusion of the renal blood vessels for 75 minutes. The test combination was studied at a dose of 30 mg/kg with daily intravenous (i.v.) administration for 3 days in comparison with quercetin (“Corvitin” medication), which was injected i.v. at a dose of 34 mg/kg. The efficacy of test drugs was assessed by the animal functional state, excretory renal function and nitrogen metabolism indicators.
Results and Discussion. Under the influence of test combination, there was a significant decrease (p<0.05) in mortality rate in rats with AKI compared to untreated animals, a decrease in diuresis by 1.5 times and proteinuria by 2.4 times, an increase in glomerular filtration by 3.0 times and tubular reabsorption by 9.9 %, creatinine and urea excretion were increased by 1.4 and 1.9 times, respectively, which indicates the normalization of kidney functional state and nitrogen metabolism. Moreover, the combination was significantly (p<0.05) superior to the Corvitin effect in efficacy level by all studied parameters.
Conclusions. Thus, the N-acetylglucosamine and quercetin combination is an effective agent for AKI treatment, which can be used at i.v. administration. It is advisable to further study of this drug as a therapy for renal pathology.
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